慢性阻塞性肺疾病患者血气分析与D-二聚体的相关性

The correlation between blood gas analysis and D-two in patients with chronic obstructive pulmonary disease

目的探讨慢性阻塞性肺疾病(COPD)患者血气分析与D二聚体(D-D)的相关性。方法回顾性选取2015年5月至2016年3月龙川县人民医院收治的50例COPD患者资料作为观察组,包括急性发作期患者30例,稳定期患者20例,另外选取25例健康体检者作为对照组,采用血凝分析仪检测受检者凝血指标和D-D,使用血气分析仪检测患者动脉血氧分压(PaO_2)及动脉血二氧化碳分压(PaCO_2)水平。结果和对照组比较,急性加重期和稳定期组患者纤维蛋白原(Fbg)、D-D及PaCO_2水平明显更高,Pa O2显著降低,差异均有统计学意义(均P<0.05);急性加重期组患者纤维蛋白原(Fbg)、D-D及PaCO_2水平显著高于稳定期组,PaO_2明显低于稳定期组,差异均有统计学意义(均P<0.05);在急性发作期组中,患者Pa O2水平和D-D水平具有负相关关系(r=-0.69,P<0.05);PaCO_2水平和D-D水平具有正相关关系(r=0.70,P<0.05)。结论 COPD患者血气分析与D-D密切相关,D-D上升,COPD患者PaO_2水平明显降低,PaCO_2水平明显上升。

Objective To investigate the correlation between blood gas analysis and D two in patients with chronic obstructive pulmonary disease.Methods 50 cases of COPD were selected in Longchuan County People＇s Hospital from May 2015 to March 2016 as the observation group,including 30 cases of patients with acute exacerbation,20 stable patients,and 25 healthy persons were selected as control group,the blood coagulation analyzer and detected the blood coagulation index and D-D,using arterial blood gas analyzer with oxygen partial pressure and arterial partial pressure of carbon dioxide level.Results Compared with the control group,acute exacerbation and stable stage group were Fbg,D-D and PaCO2 levels were significantly higher, PaO2 decreased significantly, the differences were statistically significant（P〈O.O5）;stable stage group was significantly higher than that of group Fbg,D-D and PaCO2 levels in acute exacerbation,PaO2 was significantly lower than that in stable group,the differences were statistical significance（P〈0.05）;in the acute stage group,the levels of PaO2 and D-D in patients with a negative correlation （r=-0.69,P〈0.05）;PaC02 and D-D level had a positive correlation（r=O.70,P〈0.05）.Conclusion COPD blood gas analysis was closely related to D-D,D-D increased,PaO2 levels in patients with COPD were significantly decreased, PaCO2 levels were significantly increased.