9例成人横纹肌肉瘤的临床病理学分析

Clinicopathologic features of 9 cases of adult rhabdomyosarcoma

目的·探讨成人横纹肌肉瘤(RMS)的临床病理特点及预后。方法·回顾性分析9例RMS患者临床和病理资料,及免疫组织化学检测结果。结果·该组患者平均年龄(46.89±20.09)岁,其中男性6例,女性3例。肿瘤分布范围广。组织学亚型包括胚胎性RMS 6例,腺泡状RMS、多形性RMS和梭形细胞RMS各1例。免疫组织化学检测结果显示,横纹肌标记阳性例数分别为肌细胞生成蛋白阳性6例、肌调节蛋白阳性4例、结蛋白阳性8例。7例随访中无瘤生存仅2例,带瘤生存(均为术后出现复发或转移)2例,死于肿瘤3例。结论·该组成人RMS病例中以胚胎性RMS最常见,免疫组织化学检测有助于RMS的诊断。

Objective · To investigate the clinicopathologic characteristics and prognosis of adult rhabdomyosarcoma （RMS）. Methods · The clinical and pathological data, immunohistochemical test results of 9 RMS were analyzed retrospectively. Results · The information of 6 males and 3 females were collected in this research, whose average age was （46.89±20.09） years old. The tumors had a wide range distribution. The subtypes of histology included 6 cases of embryonal RMS, 1 case of alveolar RMS, 1 case of spindle cell RMS and 1 case of pleomorphic RMS. Immunohistochemically study showed that 6 cases were myogenin positive, 4 cases were MyoD1 positive and 8 cases were desmin positive. During the follow-up period of the 7 cases, only 2 patients survived free of tumors, 2 patients presented with tumor recurrence and metastasis after the operations, and 3 patients died of tumor. Conclusion · In this study, embryonal RMS is the most common type, and immunohistochemistry test is helpful to diagnosis of RMS.