肺动脉内皮细胞在急性肺栓塞致肺动脉高压中作用的研究进展

Research progress of the role of pulmonary artery endothelial cells in pulmonary artery hypertension caused by acute pulmonary thromboembolism

急性肺栓塞(acute pulmonary thromboembolism,APTE)是呼吸系统中常见病、多发病及高病死率的疾病。急性肺栓塞发生时由于栓子阻塞肺动脉或神经体液导致血管痉挛,致使肺血管床面积骤减,引发肺血管阻力增加及肺动脉高压(pulmonary artery hypertension,PAH),严重者导致右心功能不全,最终发展成慢性肺源性心脏病(chronic cor pulmonale,CCP)。肺动脉高压是APTE发展成慢性肺源性心脏病的关键环节,其中血管内皮细胞(vascular endothelial cell,VEC)在其发病机制和治疗方面,起着十分重要作用。

Acute pulmonary thromboembolism（APTE） is a common, frequently-occurring disease with high mortality in the respiratory system. When PTE occurs, embolus blocks pulmonary artery or nerve fluid causes vasospasm, resulting in placental vascular bed area die-off, increased pulmonary vascular resistance and pulmonary artery hypertension （PAH）. In severe cases, it leads to right ventricular dysfunction and develops into chronic cor pulmonale（CCP）. Pulmonary artery hypertension is a key link in the development of APTE into chronic pulmonary heart disease, in which vascular endothelial cells （VEC） play an important role in its pathogenesis and treatment.