老年2型糖尿病合并亚临床甲状腺功能减退的临床研究

Clinical study of elderly patients with type 2 diabetes mellitus complicated with subclinical hypothyroidism

目的探讨老年2型糖尿病(T2DM)患者合并亚临床甲状腺功能减退症(SCH)的临床特点。方法收集我院2014年6月~2016年6月收治的69例T2DM合并SCH老年患者(T2DM+SCH组)和192例单纯T2DM老年患者(T2DM组)的资料及相关检查结果,并进行统计分析。结果两组的性别、年龄和吸烟史比较,差异无统计学意义(P>0.05);T2DM+SCH组的糖尿病病程、BMI值、高血压和冠心病患病率、FBG、TG、Hb A1c、HDL-C和TSH水平均高于T2DM组,差异有统计学意义(P<0.05)。T2DM+SCH组仅有FBG、TG、Hb A1c与TSH成正相关(P<0.05)。结论老年患者T2DM合并SCH在临床上较为常见,该病的病程相对较单纯T2DM患者长,BMI、Hb A1c、TG值等临床指标相对较高,易患高血压、冠心病等并发症。老年T2DM患者筛查SCH具有临床意义。

Objective To explore the clinical features of subclinical hypothyr-oidism （SCH） in elderly patients with type 2 diabetes mellitus （T2DM）.Methods The data and the test result of 69 elderly patients with T2DM combined with SCH （the T2DM＋SCH group） and 192 elderly patients with T2DM （the T2DM group） from June 2014 to June 2016 in our hospital were collected and analyzed.Results There was no significant difference in gender,age and smoking history between the T2DM＋SCH group and the T2DM group （P〉0.05）.Diabetes course,BMI,prevalence of hypertension and coronary heart disease,the level of TG,HbAlc,HDL-C and TSH in the T2DM＋SCH group was significantly higher than that in the T2DM group,with significant difference （P〈0.05）.There was a positive correlation between FBG,TG,HbA1c to TSH respectively （P〈0.05）.Conclusion Elderly patients with T2DM combined with SCH is more common in the clinical, the course of disease is long,the level of BMI,HbAlc,TG and other clinical indicators are relatively high,susceptible to high blood pressure,coronary heart disease and other complications.Elderly patients with T2DM screening SCH has clinical significance.