孕晚期无乳链球菌感染对妊娠结局的影响

Effect of group B Streptococcus infection in late pregnancy on pregnancy outcomes

目的探讨孕晚期无乳链球菌(GBS)感染对孕妇及新生儿的影响。方法选择2014年10月~2016年10月于孕晚期(28周至分娩结束)泌尿生殖道检查的80例为研究对象,将无乳链球菌培养结果为阳性者作为病例组,孕检无乳链球菌培养结果正常的孕妇作为健康组,每组各40例。通过随访比较两组孕妇产后出血、剖宫产、胎膜早破、宫内感染等不良事件发生率,并记录新生儿宫内窘迫、感染、早产等发生率。结果 80例受试者中40例出现无乳链球菌感染,病例组产后出血发生率为17.5%,宫内感染发生率为27.5%,胎膜早破发生率为12.5%,明显高于健康组(2.5%、5.0%、0),差异有统计学意义(P<0.05);病例组宫内窘迫、感染发生率依次为20.0%、17.5%,均明显高于健康组(8.0%、2.5%),差异有统计学意义(P<0.05),两组早产发生率比较,差异无统计学意义(P>0.05)。结论孕晚期无乳链球菌感染可显著增加胎膜早破、宫内窘迫及感染、早产等概率,临床需加强孕晚期筛查工作,并及时予以抗菌治疗,避免母婴不良结局。

Objective To investigate the effect of group B Streptococcus （GBS） infection in late pregnancy on pregnant women and neonates.methods A total of 80 cases of pregnant women who received genitourinary tract examination in late pregnancy （28 weeks to the end of delivery） from October 2014 to October 2016 in our hospital wgre enrolled in the study.40 patients with positive results of CBS culture were included into the case group,and 40 normal pregnant women were selected as the healthy group.The postpartum hemorrhage,cesarean section,premature rupture of membranes,intrauterine infection and other adverse events were compared between the two groups,and the incidence rates of neonatal distress,infection and premature birth were recorded.Results Among the 80 subjects,there were 40 cases of GBS infection.The incidence rate of postpartum hemorrhage,intrauterine infection and premature rupture of membranes were sig- nificantly higher in the case group than the healthy group （17.5%,27.5%,12.5% vs. 2.5%,5.0%,0） the differences were statistically significant （P〈0.05）.The incidence rate of fetal distress cases and infection were significantly higher in the case group than the healthy group （20.0%,17.5% vs. 8.0% and 2.5%） （P〈0.05）,but there was no significant difference in the incidence of preterm birth （P〉0.05）.Conclusion GBS infection in late pregnancy can significantly increase the risks of premature rupture of membranes,intrauterine distress,infection and premature birth.Screening in late pregnancy should be strengthened and timely antimicrobial therapy should be carried out to avoid adverse pregnancy outcomes.