血清激活素A对腔隙性脑梗死患者的诊断价值

The diagnostic value of serum activin A in patients with lacunar infarction

目的探讨血清激活素A(Activin-A)水平对腔隙性脑梗死(LI)患者的诊断价值。方法选择2015年2月至2016年2月该院89例因疑似LI行MRI检查患者,根据患者MRI严重程度分为4组。比较4组患者美国国立卫生院神经功能缺损评分(NIHSS)及Activin-A、超敏C反应蛋白(hs-CRP)水平,分析MRI与Activin-A的相关性。结果 LI患者MRI分级越高,NIHSS得分越高[(0.79±0.28)、(1.70±0.72)、(2.31±1.02)、(5.11±1.52)分,F=84.776,P=0.000)],血清hs-CRP[(2.68±1.55)、(5.63±1.70)、(8.04±1.66)、(10.86±2.00)mg/L,F=95.413,P=0.000)]及Activin-A水平[(17.56±4.83)、(27.63±4.39)、(31.90±5.95)、(38.47±6.78)μg/L,F=58.873,P=0.000)]也越高。Activin-A水平与hs-CRP呈正相关关系(R2=0.795,P=0.000)。LI患者发病前3dActivin-A水平逐渐增高,至第3天达高峰后逐渐下降,不同MRI分级的患者Activin-A水平差异均有统计学意义(P<0.05)。结论血清Activin-A水平与LI患者MRI分级密切相关,可作为早期预测LI患者脑损伤严重程度的特异性指标。

Objective To explore the diagnostic value of serum activin A in patients with lacunar infarction.Methods From Feb 2015 to Feb 2016,89 patients in our hospital achieved MRI test for the suspicion of accompanied with LI and were divided into 4 groups according to their MRI presentations.NIHSS scores and serum levels of hs-CRP and Activin-A were compared between these 4 groups to explore the relationship between the MRI presentations and serum levels of Activin-A in LI patients.Results Patients with higher grading in MRI presentations were also show significantly higher NIHSS scores[（0.79±0.28）,（1.70±0.72）,（2.31±1.02）,（5.11±1.52）scores,F=84.776,P=0.000],significantly higher serum levels of hs-CRP[（2.68±1.55）,（5.63±1.70）,（8.04±1.66）,（10.86±2.00）mg/L,F=95.413,P=0.000] and significantly higher levels of Activin-A[（17.56±4.83）,（27.63±4.39）,（31.90±5.95）,（38.47±6.78）μg/L,F=58.873,P=0.000].There was a positive correlation between hs-CRP and Activin-A（R2=0.795,P=0.000）.In the first 3 days,the level of Activin-A increased and then turn to decrease when reached their peak at the third day.Significant differences of serum levels Activin-A were found between different grading of MRI presentations （all P〈0.05）.Conclusion Serum levels of Activin-A were strongly associated with the grading of MRI presentations in LI patients,and could be used as an earlier specific factor for predicting the degree of brain injury.