细胞因子与非小细胞肺癌术后复发的相关性

Correlation between cytokines and non-small cell lung cancer recurrence

目的探讨穿透素3(PTX-3)、角化素蛋白片段19(CYFRA21-1)、甲状腺转录因子-1(TTF-1)的表达与非小细胞肺癌(NSCLC)术后早期复发的相关性。方法连续性纳入72例NSCLC患者,随访2年,根据随访结果分为复发组(n=26)和非复发组(n=46)。所有患者分别于术前,术后1、3个月检测血清PTX-3、CYFRA21-1、TTF-1水平。结果复发组患者术后3个月血清PTX-3、CYFRA21-1、TTF-1水平均明显升高(P<0.05)。术后1个月复发组患者血清PTX-3和TTF-1水平明显高于非复发组(P<0.05);术后3个月复发组血清PTX-3、CYFRA21-1、TTF-1水平均明显高于非复发组(P<0.05)。受试者工作特征(ROC)曲线分析术后3个月(AUC=0.823)和Δ1(AUC=0.863)PTX-3水平对NSCLC术后复发的预测价值最大。相关性分析提示PTX-3(术后3个月、Δ1和Δ2)、CYFRA21-1(术后3个月和Δ1)、TTF-1(术后3个月和Δ1)与NSCLC患者术后复发具有相关性。结论 NSCLC患者术后监测PTX-3、CYFRA21-1、TTF-1水平变化有助于肿瘤复发的早期预警监测。

Objective To investigate the relationship between the expression of-3（PTX-3）,keratin 19（CYFRA21-1） and the expression of thyroid transcription factor（TTF-1） and early postoperative recurrence of non-small cell lung cancer.Methods A total of 72 consecutive NSCLC patients were followed up for two years,according to the follow-up results were divided into relapse group（n=26） and non recurrence group（n=46）.All patients were performed before and after operation in January and March to detect the serum PTX-3,CYFRA21-1 and TTF-1 concentration.Results The recurrence group were seen 3 months after surgery,serum PTX-3,CYFRA21-1 and TTF-1 levels were significantly increased（P〈0.05）.The postoperative recurrence in January.Serum PTX-3 and TTF-1 levels were significantly higher than those in non recurrence group（P〈0.05）;postoperative recurrence 3 months group serum PTX-3,CYFRA21-1 and TTF-1 levels were significantly higher than those in non the recurrence group（P〈0.05）.ROC curve analysis indicated that serum 3 months after surgery（AUC=0.823） and the Δ1（AUC=0.863） PTX-3 level for NSCLC in predicting postoperative recurrence.The maximum value of the correlation analysis indicated that PTX-3（3 months after operation,delta Δ1 and delta Δ2） CYFRA21-1 and TTF-1 surgery（3 months after surgery and delta Δ1） were correlated to NSCLC in patients after operation.Conclusion The monitoring of PTX-3,CYFRA21-1 and TTF-1 after operation in patients with NSCLC may contribute to early warning of tumor recurrence.