复明片在未成熟期老年性白内障患者中的安全性研究

Fumingpian safety in patients with senile cataract in immature stage

目的探讨复明片在未成熟期老年性白内障患者中的应用效果及安全性。方法选取2014年1月至2016年1月该院诊断治疗的未成熟期老年性白内障患者86例,随机分为实验组和对照组。实验组46例患者85只眼,给予复明片、维生素及白内停治疗;对照组40例患者72只眼,使用障眼明片、维生素及白内停治疗。观察并比较2组患者的临床疗效、治疗前后晶状体浑浊情况、治疗后中医证侯评分,以及不良反应发生率等。结果实验组患者治疗后的临床总有效率为84.7%,对照组为70.8%,差异有统计学意义(P<0.05)。2组患者治疗前的晶状体浑浊程度比较,差异无统计学意义(P>0.05),治疗后的晶状体浑浊程度比较,差异有统计学意义(P<0.05)。治疗前后2组患者晶状体浑浊程度组内比较,差异均有统计学意义(P<0.05)。2组患者治疗前的中医证侯评分比较,差异无统计学意义(P>0.05),治疗后的中医证侯评分比较,差异有统计学意义(P<0.05)。实验组患者不良反应发生率为1.2%,对照组为9.7%,差异有统计学意义(P<0.05)。结论复明片在未成熟期老年性白内障患者中的应用效果显著,可有效缓解晶状体浑浊,降低不良反应发生率,安全性较高,具有一定的临床价值。

Objective To observe the application effect and clinical safetyof Fuming Tablet in the immature stage in senile cataract patients.Methods 86 cases of senile cataract patients in the hospital from January 2014 to January 2016 were selected as study subjects,were randomly divided into experimental group and control group.The experimental group,46 patients in 85 eyes,were given vitamin and Fuming Tablet,pirenoxine treatment,a control group of 40 patients,72 eyes,were given Zhangyanming table,pirenoxine and vitamin therapy,the clinical curative effect were observed before and after treatment,and two groups were compared and contrasted lens opacity after treatment,TCM syndrome score and the incidence of adverse reactions,analysis of Fumingpian application value in the immature stage in senile cataract patients and safety.Results The total effective rate of the experimental group after treatment was 84.7%,the control group after treatment,the total effective rate was 70.8%,the difference between the two groups was statistically significant （P〈0.05）.There was no significant difference in the degree of lens opacity before treatment between the two groups （P〉0.05）,and the difference of the degree of lens opacity after treatment was statistically significant （P〈0.05）,after treatment,the degree of lens opacity was statistically significant （P〈0.05）,the two groups of patients before and after treatment were statistically significant differences in the degree of turbidity （P〈0.05）.The two groups of patients before treatment,TCM syndrome score was no significant difference （P〉0.05）,after treatment of TCM syndrome score rol group,the difference was statistically significant （P〈0.05）.Conclusion The application effect of Fuming Tablet in the immature stage in senile cataract patients significantly,can effectively alleviate the lens opacity,reduce the incidence of adverse reaction,has high safety and certain clinical value.