二甲双胍联合炔雌醇环丙孕酮片治疗多囊卵巢综合征临床分析

Clinical aaalysis of metformin combined with ethinylestradiol and cyproterone acetate tablets on polycystic ovary syndrome

目的 探讨二甲双胍联合炔雌醇环丙孕酮片治疗多囊卵巢综合征患者的疗效及其对甲状腺功能的影响.方法 选取多囊卵巢综合征者87例,采用随机数字表法分为联合组44例、单一组43例.单一组患者采用二甲双胍治疗,联合组患者采用二甲双胍联合炔雌醇环丙孕酮片治疗,治疗后统计两组患者临床疗效、不良反应发生率,检测对比两组治疗前、后甲状腺功能.结果 联合组总有效率（95.45%）高于单一组（76.74%）,差异有统计学意义（P〈0.05）;联合组不良反应发生率（9.09%）与单一组（11.63%）比较,差异无统计学意义（P〉0.05）;治疗后,联合组TSH水平低于单一组,差异有统计学意义（P〈0.05）.结论 二甲双胍联合炔雌醇环丙孕酮片治疗多囊卵巢综合征患者疗效显著,能有效改善甲状腺功能,降低促甲状腺激素水平,且安全性高.

Objective To explore the clinical effect of mefformin combined with ethinylestradiol and cyproterone acetate tablets in patients with polycystic ovary syndrome and its effect on thyroid function. Methods A total of 87 cases of patients with polycystic ovary syndrome were selected and randomly divided into combined group （44 cases） and single group （43 cases）. The single group was treated with metformin, the treatment group was treatd with metformin combined with ethinylestradiol and cyproterone acetate tablets. After treatment, the clinical curative effect, adverse reaction, the changes of thyroid function before and after treatment were detected and compared between the two groups. Results The total effective rate of the combined group （95.45%） was higher than that of single group （76.74%）, the difference was statistically significant （P〈0.05）; the difference on the incidence rate of adverse reactions between the two groups was not statistically significant （P〉 0.05）. After treatment, the TSH level of the combined group was lower than that of the single group, the difference was statis- tically significant （P〈0.05）. Conclusion Metformin combined with ethinylestradiol and cyproterone acetate tablets in the treatment of polycystic ovary syndrome has significant curative effect, can effectively improve the thyroid function, and has high safety.