血清超敏C反应蛋白N末端B型利钠肽原检测对急性心肌梗死患者预后的影响

Effect of serum hs-CRP and NT-proBNP on the prognosis of patients with acute myocardial infarction

目的探讨血清超敏C反应蛋白(hs-CRP)和N末端B型利钠肽原(NT-proBNP)检测对急性心肌梗死患者预后的影响。方法选择2013年11月至2016年10月接受我院治疗的65例急性心肌梗死患者作为研究对象,同时选择65名我院健康工作人员作为对照组,比较患者与对照组的hs-CRP和NT-proBNF指标。结果所有患者的hs-CRP和NT-proBNF指数高于对照组,且随着患者病况严重程度,两项指数会上升,且差异具有统计学意义(P<0.05);患者治疗前,hs-CRP高于对照组[(13.0±5.8)mg/L与(3.1±1.2)mg/L],NTproBNF高于对照组[(590±202)pg/mL与(58±23)pg/mL],差异具有统计学意义(P<0.05),治疗后,治愈患者hs-CRP低于治疗前[(4.4±1.6)mg/L与(13.0±5.8)mg/L],NT-proBNF低于对照组[(65±21)pg/mL与(590±202)pg/mL],差异具有统计学意义(P<0.05);在治疗过程中,死亡的患者hs-CRP和NT-proBNP均高于治愈患者[(14.8±10.7)mg/L与(4.4±1.6)mg/L],[(988±308)pg/mL与(65±21)pg/mL],且差异具有统计学意义(P<0.05)。结论血清hs-CRP和NT-proBNP检测能够帮助临床医生预测患者的病况和预后,从而制定出更合理的治疗方案,让患者达到康复。

Objective To study effect of serum hs-CRP and NT-proBNP on the prognosis of patients with acute myocardial infarction.Methods Sixty-five patients of acute myocardial infarction who received therapy from November 2013 to October 2016 in our hospital were selected as research subjects.While 65 health workers in our hospital were selected as the control group,and the levels of hs-CRP and NT-proBNP were compared between the patients and the control group.Results All patients had higher hs-CRP and NT-proBNP index than the control group,and with the severity of the patient＇s condition,the two indices will continue to rise,and the difference was statistically significant（P〈0.05）;In patients before treatment,hs-CRP was higher than that of the control group[（13.0±5.8）mg/Lvs（3.1±1.2）mg/L[,NT-proBNP was higher than that of the control group[（65±21）pg/mL vs（590±202）pg/mLvs（58±23）pg/mL],and the difference was statistically significant（P〈0.05）;In the course of treatment,hs-CRP and NT-proBNP were higher in the patients died than cured patients[（14.8±10.7）mg/Lvs（4.4±1.6）mg/L],[（988±308）pg/mLvs（65±21）pg/mL],and the difference was statistically significant（P〈0.05）.Conclusion Serum levels of hs-CRP and NT-proBNP can help clinicians to predict the patients＇ condition and prognosis,so as to formulate a more reasonable treatment plan,so that patients can achieve rehabilitation.