不同剂量米非司酮治疗子宫肌瘤效果比较

Effect comparison of different doses of mifepristone in the treatment of uterine fibroids

目的探讨不同剂量米非司酮治疗子宫肌瘤的疗效。方法选择我院收治的子宫肌瘤患者80例作为研究对象,将患者随机为两组。对照组40例患者采用高剂量米非司酮(25 mg/d)治疗,而观察组40例患者采用低剂量米非司酮(10 mg/d)治疗,比较两组患者临床效果。结果治疗3个月后,两组患者的子宫肌瘤体积、子宫体积均缩小(P<0.05),但组间差异不显著(P>0.05);两组血清生殖激素水平均降低,且观察组低于对照组(P<0.05);观察组总有效率高于对照组(P<0.05);不良反应总发生率低于对照组(P<0.05)。结论口服低剂量米非司酮治疗子宫肌瘤疗效满意且安全性高。

Objective To investigate the curative effect of different doses of mifepristone in the treatment of uterine fibroids. Methods Eighty cases of patients with uterine fibroids admitted in our hospital were selected as the research objects, all the patients were andomly divided into control group and observation group. Forty patients in the control group accepted high dose mifepristone （25 mg/d） treatment, and 40 patients in the observation group received low dose mifepristone （10 mg/d） treatment. The clinical effects of the two groups were compared. Results After 3 months of treatment, the uterine fibroids volume, uterine volume of the two groups significantly reduced （P〈0.05）, but the difference between the two groups were not significant （P〉0.05）; the levels of serum reproductive hormone decreased in both groups, and the observation group was lower than that of the control group （P〈0.05）; the total effective rate of the observation group was higher than that of the control group （P〈0.05）; the total incidence of adverse reactions was lower than that of the control group （P〈0.05）. Conclusion Oral low dose mifepristone applied in the treatment of uterine fibroids can achieve satisfactory efficacy, which has high safety.