急性ST段抬高型心肌梗死患者血清IL-37、TGF-β的表达及其意义

Expression and significance of serum IL-37, TGF-β in patients with acute ST-segment elevation myocardial infarction

目的探讨急性ST段抬高型心肌梗死(STEMI)患者血清白细胞介素(IL)-37、转化生长因子β(TGF-β)的表达及其意义。方法选取2014年9月~2015年9月在民航总医院急诊科确诊且行经皮冠状动脉介入治疗(PCI)的STEMI患者40例作为实验组,同时选取40名常规体检者作为对照组。采用酶联免疫吸附测定(ELISA)法检测其外周血血清中IL-37、TGF-β的浓度。结果实验组患者血清IL-37浓度明显高于对照组(P=0.02),TGF-β浓度明显低于对照组,差异有统计学意义(P=0.000)。实验组IL-37与TGF-β呈负相关(r=-0.79,P=0.00),对照组IL-37与TGF-β无明显相关性(r=0.03,P=0.86)。结论 IL-37与TGF-β二者均参与STEMI的炎症过程。IL-37、TGF-β在STEMI炎性反应过程中具有负相关性,IL-37的抗炎作用发挥可能与TGF-β有关。

Objective To investigate the expression and significance of serum interleukin（IL）-37, transforming growth factor β（TGF-β） in patients with acute ST-segment elevation myocardial infarction（STEMI）. Methods Forty patients with STEMI diagnosed and taken percutaneous coronary intervention（PCI） in Department of Emergency, Civil Aviation General Hospital from September 2014 to September 2015 were selected as experimental group, and 40 normal regular healthy control were selected as control group. The concentration of serum IL-37, TGF-β in peripheral blood was detected by enzyme-linked immunosorbent assay（ELISA）. Results The concentration of serum IL-37 in experimental group was sig nificantly higher than that of control group（P = 0.02）, the concentration of TGF-β was significantly lower than that of control group, the difference was statistically significant（P = 0.000）. The concentration of IL-37 was negatively correlated with TGF-β in experimental group（r =-0.79, P = 0.00）, while there was no obvious correlation between IL-37 and TGF-βin control group（r = 0.03, P = 0.86）. Conclusion Both IL-37 and TGF-β are involved in the inflammatory process of STEMI. IL-37 and TGF-β has a negative correlation in the inflammatory process of STEMI. The anti-inflammatory effect of IL-37 may be related to TGF-β.