AMH在瘢痕妊娠行双侧子宫动脉栓塞术前和术后的动态变化

Dynamic changes of anti-müllerian hormone in cesarean scar pregnancy before and after bilateral uterine artery embolization

目的通过对血清抗苗勒管激素(AMH)的测定,评价双侧子宫动脉栓塞术对瘢痕妊娠患者卵巢储备功能的作用。方法选取我院2013年5月至2016年4月因瘢痕妊娠行双侧子宫动脉栓塞术的48例患者作为瘢痕妊娠组,采用ELISA试剂盒监测患者术前、术后1个月、术后3个月及术后6个月的血清中AMH水平,对比分析各时间段患者的血清AMH的水平。结果经过治疗,瘢痕妊娠组患者在子宫动脉栓塞术前和术后3、6个月血清AMH水平比较,无显著差异(F=0.87,P>0.05);术后1个月,患者的血清AMH水平均低于其他时间段(P<0.05);术后3个月,患者血清AMH水平较术前略有降低,术后6个月,患者血清AMH水平逐渐恢复到治疗前水平,但术后3、6个月AMH水平与治疗前比较,均无显著差异(P>0.05)。结论子宫动脉栓塞术治疗瘢痕妊娠不影响卵巢储备功能。

Objective To evaluate the effect of bilateral uterine artery embolization on ovarian reserve function in the treatment of cesarean scar pregnancy by measuring serum anti-mtillerian hormone （AMH）. Methods In our hospital from May 2013 to April 2016, 48 cases of cesarean scar pregnancy patients underwent bilateral uterine artery embolization were selected as the scar pregnancy group. The levels of serum AMH were monitored by ELISA kit before operation, 1, 3 and 6 months after operation, the levels of serum AMH in different period were compared and analyzed. Results Compared with before operation, there were no significant differences in the levels of serum AMH 3 and 6 months after operation （F=0.87, P〉0.05）; 1 month after operation, the serum AMH level was lower than those of the other periods （P〈0.05）; 3 months after operation, the serum AMH level slightly decreased, but 6 months after operation, serum AMH levels gradually returned to the level before operation, but the differences of AMH levels 3,6 months after operation and before operation were not significant （P〉0.05）. Conclusion Uterine arterial embolization in the treatment of scar pregnancy does not affect ovarian reserve function.