不同剂量瑞舒伐他汀对急性心肌梗死患者经皮冠状动脉介入治疗术后血清炎症因子及心功能相关指标的影响

Effects of different doses of rosuvastatin on serum inflammatory factors and cardiac function in patients with acute myocardial infarction after PCI

目的探讨不同剂量瑞舒伐他汀对急性心肌梗死患者经皮冠状动脉介入治疗(PCI)术后血清炎症因子及心功能的影响。方法选取2016年1月至12月我院收治的急性心肌梗死并行PCI治疗的66例患者作为研究对象,按随机数字表法分为观察组与对照组,观察组于PCI术前30min口服瑞舒伐他汀20mg,对照组于PCI术前30min口服瑞舒伐他汀10mg,2组术后均继续每天口服瑞舒伐他汀钙10mg。比较2组术后血清炎症因子及心功能的变化。结果术前,2组患者的高敏C反应蛋白(hs-CRP)、肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6水平均差异无统计学意义(P>0.05);术后7d,2组患者的hs-CRP、TNF-α、IL-6水平均比术前显著降低,且观察组低于对照组,差异均有统计学意义(P<0.05)。术前,2组左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)、左室射血分数(LVEF)差异均无统计学意义(P>0.05);术后7d,2组LVESD、LVEDD与术前比较差异无统计学意义(P>0.05),2组LVEF均比术前显著升高(P<0.05);术后30d,2组LVESD及LVEDD显著低于术前、LVEF显著高于术前,且观察组的LVESD、LVEDD低于对照组,观察组的LVEF高于对照组,差异均有统计学意义(P<0.05)。结论瑞舒伐他汀能够有效降低急性心肌梗死患者的炎症因子水平,改善其心功能,且高剂量(20mg)的效果更显著。

Objective To investigate the effects of different doses of rosuvastatin on serum inflammatory factors and cardiac function in patients with acute myocardial infarction after PCI. Methods Sixty-six patients with acute myocardial infarction treated with PCI in our hospital from January 2016 to December 2016 were ran- domly divided into observation group and control group. Patients in the observation group were treated with rosu- vastatin 20 rag, 30 minutes before PCI, while the control group received rosuvastatin 10 mg, 30 minutes before PCI. The two groups of patients were treated with rosuvastatin daily for 10 mg after PCI. The changes of serum inflammatory factors and eardiac function after PCI were compared between the two groups. Results Before PCI, there was no significant difference in hs-CRP, TNF-cx and IL-6 levels between the two groups （ P ~0.05） ; On the 7 day after PCI, the hs-CRP, TNF-a and IL-6 of the patients in the two groups were significantly lower than those before PCI, and the observation group was lower than the control group, the difference was statistically significant （ P d0. 05）. Before PCI, there was no significant difference in LVESD, LVEDD and LVEF between the two groups （ P ~0. 05） ; On the 7 day after PCI, there was no significant change in LVESD and LVEDD of the two groups （ P ~0.05）, and the LVEF of the two groups was significantly higher than that before PCI （ P d0.05） ; 30 days after PCI, LVESD and LVEDD of two groups were significantly lower than those before PCI, LVEF was signifieantly higher than that before PCI, and the observation group＇s LVESD, LVEDD were lower than those of the control group. And the observation grouprs LVEF was higher than that of the control group, the differences were statistically significant （ P〈0.05）. Conclusion Rosuvastatin can effectively decrease the level of inflamma- tory factors in patients with acute myocardial infarction and improve cardiac function. High dose （20 flag） had the more significant effect.