弓形虫表膜抗原SAG1的研究及应用进展

Advances in the study and use of the SAG1 surface antigen of Toxoplasma gondii

刚地弓形虫是一种原生动物,被其感染后引起一系列的病理变化和症状。刚地弓形虫表膜抗原SAG1是一类重要的膜蛋白,研究发现其表膜抗原SAG1在制备单克隆抗体、疫苗和临床快速诊断等方面都有着重要的作用。本文主要就弓形虫表膜抗原SAG1的分子生物学信息、SAG1在机体内的免疫应答和应用研究进行综述。

Toxoplasma gongdii is a type of parasitic protozoa. A series of pathological changes and symptoms occurs after the host is infected with T. gondii. The SAG1 surface antigen of T. gondii is an important membrane protein, and studies have found that SAG1 is a key component of the rapid clinical diagnosis of toxoplasmosis and the preparation of monoclonal antibodies （rnAbs） and vaccines. This paper reviews molecular biology information on SAG1, research on the immune response to SAG1 in vivo, and research on the use of SAG1.