肠内免疫营养对胃癌手术患者免疫功能和急性炎性反应的调理作用

Effect of enteral immunonutrition on immune function and acute inflammatory response in patients undergoing gastric cancer surgery

目的 探讨肠内免疫营养对胃癌手术患者免疫功能和急性炎性反应的调理作用.方法 选取2010年4月至2017年4月我院收治的行手术治疗的92例胃癌患者,其中40例给予肠内标准营养支持的患者归为对照组,另52例给予肠内免疫营养支持的患者归为观察组,比较两组患者术前及术后第8天免疫功能指标及急性炎性反应指标水平.结果 两组患者术后免疫功能较术前均降低,均发生急性炎性反应;观察组患者术后第8天CD4、IgG水平明显高于对照组,IL-6、CRP、TNF-α水平明显低于对照组（P＜0.05）.两组患者术后第8天的CD3、IgA、IgM水平无明显差异（P＞0.05）.结论 肠内免疫营养可有效改善胃癌手术患者术后的免疫功能,减轻急性炎性反应.

Objective To study the effect of enteral immunonutrition on immunonutrition function and acute inflammatory response in patients with gastric cancer. Methods Ninety-two patients with gastric cancer who were treated surgically in our hospital from April 2010 to April 2017 were selected. And 40 cases treated with enteral nutrition support were classified to control group, the other 52 cases received enteral immunonutrition were classified to observation group. The levels of immune function and acute inflammatory reaction in the two groups before and 8 days after the surgery were compared. Results The postoperative immune function decreased in both of the two groups, and acute inflammatory reaction were occurred in both of the two groups; the level of CD4 and IgG in the observation group at 8 days after the surgery were significantly higher than those of the control group, the serum IL-6, CRP and TNF-α levels were significantly lower than those of the control group （P〈0.05）. There was no significant differences in CD3, IgA and IgM levels between the two groups at 8 days after the surgery （P〉0.05）. Conclusion Enteral immunonutrition can effectively improve the postoperative immune function of gastric cancer patients and reduce the acute inflammatory reaction.