甲状腺内联合注射激素和环磷酰胺治疗亚急性甲状腺炎的疗效

Clinical effect of intrathyroid injection of hormone combined with cyclophosphamide on the treatment of subacute thyroiditis

目的 研究分析对亚急性甲状腺炎患者进行甲状腺内注射激素联合环磷酰胺的双重免疫调节治疗的临床效果.方法 选取2011年4月至2016年12月于我院就诊的亚急性甲状腺炎患者40例,随机分为试验组和对照组,各20例,试验组采用甲状腺内注射地塞米松联合环磷酰胺治疗,对照组给予甲状腺内仅注射地塞米松治疗.对患者治疗前后的体温、甲状腺疼痛情况、甲状腺体积进行观察比较,同时记录分析患者的血沉、FT3水平、FT4水平、口服碘剂后3 h的131I的吸收率及治疗总有效率.结果 试验组患者的治疗总有效率明显高于对照组（P＜0.05）;试验组患者的退热时间、甲状腺疼痛减轻时间、甲状腺体积缩小时间、治疗时间均明显短于对照组,差异具有统计学意义（P＜0.05）;试验组患者治疗后的血沉、FT3水平、FT4水平明显低于对照组（P＜0.05）;治疗后,试验组患者口服碘剂后3 h的131I的吸收率显著高于对照组（P＜0.05）.结论 甲状腺内注射地塞米松联合环磷酰胺进行双重免疫治疗可显著改善亚急性甲状腺炎患者的临床症状,疗效显著,且见效快.

Objective To study the clinical effect of intrathyroid injection of hormone combined with cyclophosphamide on the treatment of subaeute thyroiditis. Methods Forty cases of patients with subacute thyroiditis in our hospital from April 2011 to December 2016 were selected as research objects. All patients were randomly divided into experimental group and control group, with 20 cases in each group. Patients in the experimental group were treated with intrathyroid injection of hormone combined with eyclophosphamide, while the patients in the control group were treated with intrathyroid injection of hormone. The body temperature, thyroid pain situation, the volume of thyroid gland, erythrocyte sedimentation rate, FT3, FT4 and 3 h absorption rate of 131I after oral before and after treatment were observed and compared between the two groups. Results The cure rate of experimental group was significantly higher than that of the control group （P〈0.05）; The recovery time of fever, the duration of thyroid pain, the time of thyroid volume reduction, the treatment time, erythrocyte sedimentation rate, FT3, FT4 of the experimental group were significantly shorter or lower than those of the control group, and the differences were statistically significant （P〈0.05）; after treatment, the 3 h absorption rate of 131I after oral of experimental group was significantly higher than that of the control group （P〈0.05）. Conclusion Intrathyroid injection of hormone combined with cyclophosphamide has remark- able clinical effect on subacute thyroiditis, can significantly and speedy improve the clinical symptom of patients.