输尿管上路结石并发尿路感染患者尿病原微生物及耐药性分析

Analysis of urinary pathogenic microorganisms and drug resistance in patients with ureteral calculi complicated with urinary tract infection

目的 分析输尿管上路结石并发尿路感染患者尿病原微生物及药敏试验结果,为指导输尿管上路结石患者术后尿路感染抗生素合理使用提供参考.方法 收集2012年10月至2015年11月我院310例输尿管上路结石并发尿路感染患者的临床资料,回顾性分析患者尿液中细菌分布情况及其耐药情况.结果 310例输尿管上路结石并发尿路感染患者尿液中,共检测出320例菌株.其中革兰阳性菌为44株（13.75%）,革兰阴性菌为272株（85.00%）,真菌为4株（1.25%）;革兰阳性菌对红霉素、四环素等抗生素耐药性较高;革兰阴性菌对氨苄西林、头孢唑林、呋喃妥因、头孢他啶等抗生素耐药性较高.结论 经尿病原微生物分布分析可知,大肠埃希菌感染是导致我院输尿管上路结石患者术后尿路感染的主要病原微生物;且药敏试验结果显示,革兰阳性菌对红霉素、四环素等具有较高耐药性;革兰阴性菌对氨苄西林、头孢唑林、呋喃妥因、头孢他啶等具有较高耐药性.

Objective To analyze the results of urine pathogenic microorganisms and drug susceptibility test in patients with ureteral calculi complicated with urinary tract infection, to provide reference for the rational use of antibiotics in postop- erative urinary tract infection in patients with ureteral calculi. Methods From October 2012 to November 2015, the clinical data of 310 patients with ureteral calculi complicated with urinary tract infection in our hospital were collected, and the dis- tribution of bacteria in the urine and its drug resistance were retrospectively analyzed. Results The 310 cases of patients with ureteral calculi complicated with urinary tract infection were detected a total of 320 strains. There were 44 strains of Gram- positive bacteria （13.75%）, 272 strains of Gram-negative bacteria （85.00%） and 4 strains of fungi （1.25%）; Gram-positive bacteria were more resistant to erythromycin, tetracycline and other antibiotics, Gram-negative bacteria were more resistant to ampicillin, cefazolin, nitrofurantoin, ceftazidime and other antibiotic resistance. Conclusion The urethral microbes distri- bution shows that Escherichia coli infection is the main pathogenic microorganism caused urinary tract infection in patients with ureteral calculi, and drug susceptibility test results show that Gram-positive bacteria were more resistant to ery- thromycin, tetracycline and other antibiotics, Gram-negative bacteria were more resistant to ampicillin, cefazolin, nitrofuran- toin, ceftazidime and other antibiotic resistance.