黎氏哮喘1号方对小儿哮喘的临床疗效及血清学指标的影响

Effect of LI's No.1 Asthma Perscription on Clinical Efficacy and Serological Markers in Children with Asthma

目的:研究小儿哮喘治疗中黎氏哮喘1号方对临床疗效及血清学指标的影响。方法:选取180例小儿支气管哮喘患儿作为哮喘组。将哮喘组患儿按家长意愿选择治疗方案不同分为治疗组(n=84)和对照组(n=96),其中治疗组患儿采用黎氏哮喘1号方联合雾化布地奈德、异丙托溴铵、沙丁胺醇三联药物治疗,而对照组患儿采用雾化布地奈德、异丙托溴铵、沙丁胺醇三联药物治疗,同时选取160例正常小儿作为正常组。比较治疗组和对照组患儿临床疗效,正常组和哮喘组患儿治疗前IL-18、IgE、TNF-α、C反应蛋白、前白蛋白、白细胞计数、嗜酸性粒细胞百分比和中性粒细胞百分比等血清学指标,比较治疗组和对照组患儿治疗前后IL-18、IgE、TNF-α、C-反应蛋白、前白蛋白、白细胞计数、嗜酸性粒细胞百分比和中性粒细胞百分比。结果:治疗组患儿治疗后症状积分明显低于对照组,两组患儿治疗后症状积分均明显低于各自治疗前(P<0.05)。哮喘组患儿治疗前的IL-18、IgE、TNF-α、C-反应蛋白、白细胞计数、嗜酸性粒细胞百分比和中性粒细胞百分比水平明显高于正常组,哮喘组患儿前白蛋白明显低于正常组(P<0.05)。治疗组患儿的治疗后血清C-反应蛋白、白细胞计数、嗜酸性粒细胞百分比、中性粒细胞百分比、IL-18、IgE、TNF-α水平明显低于对照组患儿,两组患儿治疗后血清C-反应蛋白、白细胞计数、嗜酸性粒细胞百分比、中性粒细胞百分比、IL-18、IgE、TNF-α水平均低于各自治疗前,且差异均有统计学意义(P<0.05)。治疗组患儿的治疗后血清前白蛋白水平明显高于对照组患儿,两组患儿治疗后血清前白蛋白水平均高于各自治疗前,且差异均有统计学意义(P<0.05)。结论:小儿哮喘治疗中,黎氏哮喘方联合雾化吸入布地奈德等三联药物可减轻炎性反应,降低C反应蛋白、前白蛋白、白细胞计数、嗜酸性粒细胞百分比、中性粒细胞百分比等血清学指标,有效发挥抗炎作用,双向调节Th1/Th2细胞,具有一定抗过敏作用,可有效治疗轻中度哮喘。

Objective： To study the effect of LI＇s No.l asthma perscription on clinical efficacy and serologi- cal markers in children with asthma. Methods： The 180 children with asthma was chosen as asthma group, di- vided them into treatment group 01=84） and control group （n=96）. The treatment group was treated with LI＇s No. 1 asthma perscription combined with Budesonide atomization, ipratropium bromide and salbutamol, while the control group was treated with Budesonide atomization, ipratropium bromide and salhutamol. And select 160 nor- real cases at the same time as normal group. Compare the clinical efficacy, the IL-18, Ig E, TNF-α, C-reac- tion protein, prealbumin, white blood cell count, pereentage of eosinophils and percentage of neutrophil of pre- treatment of asthma group anti normal group. Results： The, symptom scores of post-treatment of treatment group was much less than control group, the symptom scores of post-treatment of two groups were much less than pre-treatment respectively （P〈0.05）. The pre-treatment IL-18 , IgE, TNF-α, C-reaetion protein, prealbumin, white blood cell count, percentage of eosinophils and percentage of neutrophil level of asthma group were much higher than control group, the prealbumin level of asthma group was much less than normal group （P〈0.05）. The IL-18, Ig E, TNF-α, C-reaction protein, white blood cell count, percentage of eosinophils and percentage ofneutrophil of integrated traditional Chinese and western medicine group were much less than western medicine group, the IL-18, Ig E, TNF-α, C-reaction protein, white blood cell count, percentage of eosinophils of post- treatment of two groups were much less than pre-treatment respectively （P〈0.05）. The prealbumin of treatment group were much more than control group, the prealbumin of post-treatment of two groups were much more than pre-treatment respectively （P〈0.05）. Conclusion： Ll＇s No.1 asthma perscription combined with Budesonide atomiza- tion could relieve the inflammatory reaction, reduce the C-reaction protein, prealbumin, white blood cell count, percentage of eosinophils and percentage of neutrophil level, effectively exert anti-inflammatory effects, regulate Th1/Th2 cell, has certain anti allergic effect, can be effective in the treatment of mild to moderate asthma.