三结构域蛋白（TRIM）家族结构及功能的研究进展

Structures and functions of tripartite-motif proteins

三结构域蛋白（TRIM）家族具有高度保守RBCC结构域,从N端到C端的顺序依次是RING锌指结构,一个或两个B-box结构域和一个卷曲螺旋结构域,RBCC结构域后是高度可变的C端结构域.TRIM蛋白家族不仅能够维持机体正常生理功能,还参与多种疾病发病机制的调控过程.本文主要对TRIM家族的结构特点及其在病毒感染、肿瘤、神经退行性疾病中发挥的功能进行综述.

Members of the tripartite-motif （TRIM） protein family share a highly conserved domain architecture known as RBCC motif,which is composed of a RING finger domain,one or two B-box domains,a coiled-coil domain as well as diverse types of C-terminal regions.TRIM proteins can not only maintain the normal physiological functions of the body,but also regulate the development of various diseases.In the current review,we focus on recent advances in the structures of TRIM proteins and their functions in the development of viral infection,cancer and neurodegenerative disease.