艾司洛尔治疗心房纤颤伴快速心室率合并射血分数保留的心力衰竭的疗效

The Clinical Effect of Esmolol in the Treatment of Heart Failure With Preserved Ejection Fraction Patients With Rapid Atrial Fibrillation

目的观察静脉微量泵注艾司洛尔治疗心房纤颤伴快速心室率合并射血分数保留的心力衰竭的疗效。方法对48例心房纤颤伴快速心室率合并射血分数保留的心力衰竭的患者进行常规治疗基础上,以静脉微量泵注艾司洛尔[0.05~0.20 mg/(kg·min)],观察用药(5min、10 min、30 min、1 h、2 h、12 h)血压、心率、症状、体征和血浆脑钠肽(BNP)等指标。结果治疗前后比较,心室率下降有效率90%,心功能改善有效42例,总有效率为87%;BNP较用药前有所降低,差异有统计学意义(P<0.05),无明显不良反应。结论静脉微量泵注艾司洛尔可以有效治疗心房纤颤伴快速心室率合并射血分数保留的心力衰竭的患者。

Objective To observe the clinical effects of esmolol in the treatment of heart failure with preserved ejection fraction patients with rapid atrial fibrillation. Methods 48 patients of preserved ejection fraction patients with rapid atrial fibrillation were treated with esmolol [0.05-0.20 mg/（kg.min）]. And observed the efficiency, symptoms, signs, heart rate, blood pressure changes and BNP before and after treatment（5 min, 10 min, 30 min, 1 h, 2 h, 12 h）. Results Compared with administration before, the efficacy rate of the heart rate decline was 90%, the heart function of 42 patients improved, and the total efficacy rate was 87%, and BNP decreased, The difference was statistically significant （P〈0.05）. There was no significant adverse reaction. Conclusion Intravenous esmolol has significant therapeutic effects of heart failure with preserved ejection fraction patients with rapid atrial fibrillation.