可溶性鸟苷酸环化酶基因特性及其与高血压关联性的研究进展

Research advance in gene characteristics of soluble guanylate cyclase and the correlation of its polymorphisms with hypertension

可溶性鸟苷酸环化酶(soluble guanylate cyclase,sGC)作为一氧化氮(nitric oxide,NO)的唯一受体,是NO信号转导通路中的一个关键核心金属酶,在NO-环磷酸鸟苷(cyclic guanosinc monophosphate,cGMP)通路中起到非常重要的中介作用,对血压和肾排泄钠的调节有重要作用。近年来,国内外学者对sGC的结构、功能、激活机制及其在生理、病理中的作用做了大量研究,本文重点对sGC的生物学特性及其与高血压关联性的研究现况作一综述。

As the only receptor of nitric oxide（NO）and the key metal enzyme in the NO signal transduction pathway, soluble guanylate cyelase （SGC） plays an important intermediation role in the NO-cGMP pathway and the regulation of blood pressure and renal sodium excretion. In recent years, researchers at home and abroad have done much studies on its construction, function, activation mechanism, and roles in physiology and pathology. This article reviews current advances in the gene characteristics of SGC and its correlation with hypertension.