评价经支气管镜气道支架植入治疗甲状腺癌侵犯气管中气道狭窄的临床效果、并发症及预后

Evaluation of the clinical effect, complications and prognosis of bronchoscopic airway stent implantation in the treatment of airway stenosis caused by invasion of thyroid carcinoma

目的对支气管镜气道支架植入治疗甲状腺癌侵犯气管中气道狭窄的临床效果、并发症及预后进行评价。方法选取2012年9月~2014年1月我院收治的甲状腺癌侵犯气管中气道狭窄患者46例作为观察对象,按照数字表法分为对照组(n=23)和治疗组(n=23),对照组给予常规治疗,治疗组给予经支气管镜气道支架植入治疗,对两组临床效果、并发症发生率及预后情况进行观察和评比。结果两组总缓解率比较,治疗组总缓解率为87.0%,高于对照组的52.2%,差异有统计学意义(P<0.05);治疗组的并发症发生率为17.4%,低于对照组的47.8%,差异有统计学意义(P<0.05);两组术后3年存活率、死亡率比较,治疗组均比对照组优势明显,组间差异有统计学意义(P<0.05)。结论经支气管镜气道支架植入治疗甲状腺癌侵犯气管中气道狭窄效果确切,并发症发生率低,预后良好,值得临床优先选择和普及应用。

Objective To evaluate the clinical effect, complications and prognosis of bronchoscopic airway stem im- plantation in the treatment of airway stenosis caused by invasion of thyroid carcinoma. Methods A total of 46 patients with airway stenosis caused by invasion of thyroid carcinoma who were admitted to our hospital from September 2009 to January 2014 were selected as the observation subjects. The patients were divided into the control group（n=23） and the treatment group （n=23） according to the number table method. The control group was given conventional therapy, and the treatment group was given bronchoscopic airway stent implantation. The clinical effects, the incidence rate of complications and prognosis were observed and evaluated in both groups. Results The total remission rate was compared between the two groups, and the total remission rate was 87.0% in the treatment group, higher than that of 52.2% in the control group, and the difference between groups was significant（P〈0.05）; the incidence rate of complications in the treatment group was 17.4%, lower than that of 47.8% in the control group, and the difference was statistically significant（P〈0.05）; the survival rate and mortality rate 3 years after the surgery were compared between the two groups, and the treatment group had significant advantages compared with the control group. The differences between groups were statistically significant（P〈0.05）. Conclusion The bronchoscopic airway stent implantation in the treatment of airway stenosis caused by invasion of thyroid carcinoma has an exact curative effect, with low incidence of complications and good prognosis, which is worthy of clinical preference, popularization and application.