丁苯肽针治疗发病72h内急性脑梗死患者临床疗效及预后分析

Clinical efficacy and prognosis of patients with acute cerebral infarction within 72h of onset treated with butylbenzene peptide injection

目的研究丁苯肽针治疗发病72 h内急性脑梗死患者临床疗效及预后分析。方法采用纵向列研究设计方法,随访本院2014年6月~2016年7月神经内科收住的急性脑梗死患者107例,随机分为试验组54例和对照组53例,对照组患者仅接受常规治疗,试验组则在常规治疗上增加丁苯肽针治疗,比较两组患者的临床治疗效果、神经功能缺损评分、治疗前后凝血指标水平及治疗前后红细胞比积与血小板聚集率变化。结果观察组治疗有效率为87.04%,对照组治疗有效率为58.49%,组间比较差异有统计学意义(P<0.05)。急性脑梗死患者发病72 h后观察组患者的临床治疗效果、神经功能缺损评分、凝血指标水平及红细胞比积与血小板聚集率变化均低于对照组,差异有统计学意义(P<0.05)。结论丁苯肽针治疗发病72 h内急性脑梗死有显著效果,适合广泛推广。

Objective To study the clinical efficacy and prognosis of patients with acute cerebral infarction treated with butanol peptide for 72 hours. Methods A total of 107 patients with acute cerebral infarction admitted in our hospital from June 2014 to July 2016 were followed up, using vertical design method. The patients were randomly divided into experimental group（n=54）and control group（n=53）. The control group received routine treatment only, while the experimental group was treated with butylbenzene peptide based on the conventional treatment. The changes of clinical treat- ment effect, neurological deficit score, coagulation index before and after treatment, erythrocyte ratio before and after treatment and platelet aggregation rate between the two groups were compared. Results The effective rate was 87.04% in the experimental group and that of 58.49% in the control group, and the difference was statistically significant （P〈 0.05）. The clinical treatment effect, neurological deficit score, coagulation index before and after treatment, and the changes of erythrocyte ratio and platelet aggregation in the observation group after 72 h of onset in patients with acute cerebral infarction, which were lower than those in the control group, and the differences were statistically significant （P〈0.05）. Conclusion Butylbenzene peptide injection has a significant effect in the treatment of acute cerebral infarction within 72 hours of onset, which is suitable for extensive promotion.