纳洛酮联合醒脑静治疗重型颅脑外伤的疗效观察

Clinical Observation on Naloxone Combined With Xingnaojing Injection for the Treatment of Severe Craniocerebral Injury

目的探讨纳洛酮联合醒脑静注射液治疗重度颅脑外伤患者的临床效果。方法选择2014年1月—2016年12月我院收治的120例重症颅脑外伤患者作为研究对象,将其随机分为观察组和对照组,每组各60例。对照组用纳洛酮治疗,观察组给予纳洛酮联合醒脑静注射液,对两组患者的临床治愈率、有效率、GCS、GOS评分以及不良反应情况进行对比分析。结果治疗后,观察组临床治愈率、总有效率、GCS与GOS评分均优于对照组(均P<0.05);两组患者的不良反应率对比,差异不具有统计学意义(P>0.05)。结论纳洛酮联合醒脑静注射液治疗重度颅脑外伤可以促进神经功能快速恢复,安全可靠。

Objective To explore the clinical effects of naloxone combined with Xingnaojing injection for severe craniocerebral injury. Methods 120 cases with severe craniocerebral injury from January 2014 to December 2016 were selected and divided into observation group （n=60） and control group （n=60）. The control group was taken naloxone and the obs-rvation group was taken naloxone combined with Xingnaojing injection. The total effective rate, clinical curative rate, GCS score, GOS score and adverse reaction were compared. Results In observation group, the total effective rate, clinical curative rate, GCS and GOS score were significant better than control group, the difference was statistically significant （P〈0.05）. There was no significant difference of adverse reaction between two groups, the difference was not statistically significant （P〉0.05）. Conclusion The combination of naloxone and Xingnaojing injection can promote the functional rehabilitation of injured nerve for severe cniniocerebral injury patients.