IL-6 C-572G多态性位点与自发性早产遗传易感性的关系

Association between IL-6 C-572G and susceptibility to spontaneous preterm birth

目的探讨IL-6基因C-572G多态性位点与自发性早产(SPTB)遗传易感性的关联性。方法研究对象来自北京及其周边地区。病例组包括569例SPTB新生儿,其中超早产儿(胎龄<28周)56例、极早产儿(胎龄28~31^(+6)周)166例和中晚期早产儿(胎龄32~36^(+6)周)347例。对照组包括673例足月新生儿。采用最新的Sequenom Mass ARRAY~?SNP检测技术对IL-6基因C-572G位点进行单核苷酸多态性分型。结果与携带IL-6基因C-572G位点的CC基因型的个体相比,携带至少1个G等位基因型(CG+GG基因型)的个体发生中晚期SPTB的风险显著升高(OR=1.35,95%CI:1.01~1.80,P=0.04)。结论在该中国人群中,IL-6基因C-572G多态性位点与中晚期SPTB患病风险的增加存在显著的遗传学关联。

Objective To investigate the association between the genetic polymorphism of IL-6 C-572G and susceptibility to spontaneous preterm birth （SPTB）. Methods The subjects were from Beijing and the surrounding areas of Beijing. This case-control study enrolled 569 SPTB infants, including 56 extremely preterm （〈28 weeks of gestation）, 166 very preterm （28-31＋6 weeks of gestation） and 347 moderate to late preterm infants （32 to 36＋6 weeks of gestation）. A total of 673 term infants were enrolled as the control group. The latest Sequenom MassARRAYSNP detection technique was used for the typing of single nucleotide polymorphism of IL-6 C-572G. Results Compared with the CC genotypes, the IL-6 C-572G G-positive genotype （CG＋GG genotype） was significantly associated with an increased susceptibility to moderate to late SPTB （OR=1.35, 95%CI： 1.01-1.80, P=0.04）. Conclusions Among the Chinese population, IL-6 C-572G polymorphism is associated with susceptibility to moderate to late SPTB. [Chin J Contemp Pediatr, 2017, 19（7）： 806-811]