IgA血管炎免疫学发病机制的研究进展

Research advances in immunological pathogenesis of immunoglobulin A vasculitis

IgA血管炎(IgAV)是儿童最常见的白细胞碎裂性小血管炎,主要累及皮肤小血管、关节、消化道及肾脏,其发病机制并不完全明确。目前认为是在遗传的基础上,受环境影响,引起自身免疫系统功能紊乱,IgA为主的免疫复合物在小动脉壁沉积而发病。该文主要探讨免疫因素在IgAV发病机制中的作用。

Immunoglobulin A （IgA） vasculitis is the most common leukocytoclastic small-vessel vasculitis in children and mainly involves the small vessels in the skin, joints, digestive tract, and kidneys. Its pathogenesis is still unclear. Currently, it is believed that environmental factors can cause autoimmune dysfunction and lead to the deposition of IgA-containing immune complexes on the wall of arterioles on the basis of genetic factors. This article reviews the research advances in the role of immune factors in the pathogenesis of IgA vasculitis.