首发精神分裂症患者认知功能和临床特征与脑源性生长因子基因Va166Met多态性的相关性

Association of Va166Met polymorphism of brain-derived neurotrophic factor gene with cognitive impairment ano clinical symptoms in first-episode schizophrenia

目的探讨首发精神分裂症患者的认知功能损害和临床特征与脑源性生长因子（brain-derivedneurotrophicfactor，BDNF）基因Va166Met多态性的相关性。方法采用TaqMan荧光探针技术对87例首发精神分裂症患者和76名对照者BDNF基因的Va166Met（rs6265）多态性进行检测，采用韦氏智力成人版测试进行认知功能评估，分析诊断和基因多态性对智商交互影响，并对患者异常的智商与临床症状严重程度进行相关性分析。结果患者组总智商、言语智商和操作智商和对照组比较出现显著下降。总智商（F=4．59，P=0．01）和言语智商（F=4．44，P=0．01）下降受基因和诊断交互作用的影响，Val／Val基因型患者言语智商低于Val／Met和Met／Met基因型患者，而Met／Met基因型对照者言语智商低于Val／Met基因型，Met／Met基因型对照者总智商小于Val／Met和Val／Val基因型对照者。精神分裂症Val／Val基因型者总智商与阳性症状分（r=-0．65，P=0．03）和思维紊乱（r==0．61，P=0．02）症状呈负相关。结论首发精神分裂症患者认知功能损害、临床特征与BDNF基因Va166Met多态性相关，BDNFVa166等位基因是精神分裂症易感基因。

Objective To assess the association of cognitive impairment and clinical symptoms in first- episode schizophrenia with the Va166Met （rs6265） polymorphism of brain-derived neurotrophic factor （BDNF） gene. Methods For 87 patients with first-episode schizophrenia and 76 healthy controls, the Va166Met polymorphism was determined with a Taqman Assay-on-Demand method. Wechsler intelligence test was carried out for all participants. Correlation of cognitive impairment with clinical severity was also analyzed. Results The patients were significantly lower in total IQ, verbal IQ and performance IQ compared to the controls. The lower total IQ （F=4.59, P=0.01） and verbal IQ （F=4.44, P=0.01） were influenced by genetic factors and diagnostic interaction. The vertal IQ of Val/Val patients was significantly lower than those of Val/Met and Met/Met carriers. For the control group, the verbal IQ of Met/Met carriers was lower than that of Val/Met carriers, and the total IQ of Met/Met carriers was lower than those of Val/Met and Val/Val carriers. For the patient group, the total IQ of Val/Val carriers was negatively correlated with positive symptoms （r= - 0.65, P = 0.03） and thought disorders （r= - 0.61, P=0.02）. Conclusion Cognitive impairment in first-episode schizophrenic patients is associated with the Va166Met polymorphism of the BDNF gene, and has an important clinical relevance.