银屑病性关节炎易感基因的研究进展

Progress in genetic research on psoriatic arthritis

银屑病性关节炎是一种与银屑病相关的炎性关节病，患者有银屑病皮疹并伴有关节和周围软组织疼痛、肿胀、压痛、僵硬和运动障碍。流行病学研究显示银屑病性关节炎较寻常型银屑病的遗传度更高，受遗传因素影响大。研究表明MHc、TNF、LCE、IL23R、IL12B和TRAF3IP2、TNFAIP3等多个易感基因位点在这两种表型中是重叠的，但也有研究结果显示在MHC、IL—13、PTPN22中一些易感基因位点只和银屑病性关节炎相关。本文对银屑病性关节炎和寻常型银屑病的易感基因进行综述，以期为银屑病性关节炎患病风险预测、早期诊断及药物研发奠定重要基础。

Psoriatic arthritis is a form of inflammatory arthritis found among patients with psoriasis, which can lead to pain, swelling or stiffness in one or more joints and even movement disorders. Epidemiological studies have shown a higher heritability for psoriatic arthritis compared with psoriasis vulgaris. With the evolvement of DNA sequencing, many genes have been associated with psoriasis vulgaris and psoriatic arthritis, which included MHC, TNF, LCE, IL23R, IL12B, TRAF3IP2 and TNFAIP3, though some, such as MHC, IL-13 and PTPN22, have been specifically associated with psoriatic arthritis. These studies have laid a foundation for risk prediction, diagnosis and drug development for psoriatic arthritis.