慢性心理应激与免疫

Chronic psychological stress and immunity

我国正处于快速发展的转型期,社会心理问题日益突出。尽管目前对慢性心理应激影响免疫的负面效应有了较清楚的认识,但对相关机制仍了解甚少,因而对其危害还缺乏有效的干预手段。近些年来,国内外的研究比较关注慢性心理应激影响免疫的分子基础、对免疫效应细胞的调控作用和对免疫调节细胞的调控作用,本文对相关进展进行简要综述。

With the rapid development of our country,people are facing more and more psychological problems. It has been demonstrated that persistent stress and depression, which leads to continuously elevated levels of stress hormones, might eventually com- promise host defenses against bacterial or viral infection while increasing the reoccurance of autoimmunity and the incidence of malignancy/metastasis. Even though the molecular mechanisms by which chronic psychological stress inhibits the effector subsets in the immune system have been partially disclosed, it remains elusive whether chronic psychological stress also affects the regulatory subsets and if yes,what are the underlying mechanisms. Here,we review the findings in this field.