摘要
目的:研究白塞病及常见免疫风湿性疾病血清维生素A(sVit A)水平。方法:化学发光法测得白塞病(BD,包括眼BD、肠BD、血管BD等3种罕见亚型)、类风湿关节炎(RA)、系统性红斑狼疮(SLE)、强直性脊柱炎(AS)、原发干燥综合征(p SS)和成年发病Still病(AOSD)等6种疾病sVit A水平,并与50例健康对照组(HC)进行比较,其中针对RA、SLE、AS和pSS对HC进行配对设计后比较。结果:纳入的各种风湿性疾病符合相应的流行病学特点;眼BD、肠BD、血管BD及皮肤黏膜型BD sVit A水平均低于健康人群(P<0.05),组间无差异;RA、SLE、AS、pSS和AOSD sVit A水平均低于健康人群(P<0.05)。结论:sVit A浓度下降可能是多种免疫风湿性疾病的共同机制。
Objective:To investigate the serum Vitamin A( sVit A) levels in Behcet's disease (BD)and other rheumatological diseases. Methods: sVit A concentration was measured in BD ( including 3 subtypes of eye BD, intestinal BD, and vascular BD), rheumatoid arthritis ( RA), systemic lupus erythematosus ( SLE ), ankylosing spondylitis ( AS ), primary Sjogren' s syndrome ( pSS ) and adult onset Still disease(AOSD) and compared with healthy controls(HC). Results: The patients enrolled in this study was according with the epidemiological features ; BD patients including its subtypes of eye BD, intestinal BD, and vascular BD patients all had a lower concentration of sVit A than HC (P〈0. 05), no statistical differences between the subtypes; RA, SLE, AS, pSS and AOSD had a lower concentration of sVit A than HC( P〈0.05 ). Conclusion: Decreased serum Vit A levels might account for a common pathogenesis of various rheumatic diseases.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2017年第7期1068-1071,共4页
Chinese Journal of Immunology
基金
上海卫生系统第二批重要疾病联合攻关重点项目(2014ZYJB0010)
关键词
白塞病
自身免疫
风湿病
维生素A
视黄酸
流行病学
Behcet's disease
Autoimmune
Rheumatology
Vitamin A
Retinoic acid
Epidemiology