风湿性疾病血清维生素A水平下降

Serum Vitamin A is decreased in rheumatological diseases

目的:研究白塞病及常见免疫风湿性疾病血清维生素A(sVit A)水平。方法:化学发光法测得白塞病(BD,包括眼BD、肠BD、血管BD等3种罕见亚型)、类风湿关节炎(RA)、系统性红斑狼疮(SLE)、强直性脊柱炎(AS)、原发干燥综合征(p SS)和成年发病Still病(AOSD)等6种疾病sVit A水平,并与50例健康对照组(HC)进行比较,其中针对RA、SLE、AS和pSS对HC进行配对设计后比较。结果:纳入的各种风湿性疾病符合相应的流行病学特点;眼BD、肠BD、血管BD及皮肤黏膜型BD sVit A水平均低于健康人群(P<0.05),组间无差异;RA、SLE、AS、pSS和AOSD sVit A水平均低于健康人群(P<0.05)。结论:sVit A浓度下降可能是多种免疫风湿性疾病的共同机制。

Objective：To investigate the serum Vitamin A（ sVit A） levels in Behcet＇s disease （BD）and other rheumatological diseases. Methods： sVit A concentration was measured in BD （ including 3 subtypes of eye BD, intestinal BD, and vascular BD）, rheumatoid arthritis （ RA）, systemic lupus erythematosus （ SLE ）, ankylosing spondylitis （ AS ）, primary Sjogren＇ s syndrome （ pSS ） and adult onset Still disease（AOSD） and compared with healthy controls（HC）. Results： The patients enrolled in this study was according with the epidemiological features ; BD patients including its subtypes of eye BD, intestinal BD, and vascular BD patients all had a lower concentration of sVit A than HC （P〈0. 05）, no statistical differences between the subtypes; RA, SLE, AS, pSS and AOSD had a lower concentration of sVit A than HC（ P〈0.05 ）. Conclusion： Decreased serum Vit A levels might account for a common pathogenesis of various rheumatic diseases.