CYP4F2基因多态性与云南汉族人群冠心病的相关性研究

Study of the correlation between the gene polymorphism of CYP24F2 and coronary heart disease in Yunnan Han population

目的:研究CYP4F2基因多态性与中国云南汉族人群冠心病(CHD)的相关性。方法:采用Sequenom Mass ARRAY对云南汉族人群198名正常人(对照组)和514例CHD病人(CHD组)CYP4F2基因rs2108622、rs3093135两个单核苷酸多肽位点的多态性进行基因分型,分析该基因多态性与CHD的相关性。结果:对照组和CHD组两个等位基因频率分布差异有统计学意义(P<0.01);校正年龄、性别、体质量指数等因素后logistic回归分析显示rs2108622位点携带T等位基因者患CHD的风险降低(P<0.05);rs3093135位点携带A等位基因者患CHD风险降低(P<0.05)。结论:CYP4F2基因多态性与云南汉族人群CHD发生风险相关。

Objective：To investigate the correlation between the gene polymorphism of CYP4F2 and coronary heart disease（CHD） in Yunnan Han population.Methods：The polymorphisms of rs2108622 and rs3093135 single nucleotide polymorphism（SNP） in CYP4F2 gene of 198 normal people（control group） and 514 patients with CHD（CHD group） were genotyped using the SEQUENOM Mass-ARRAY system.The correlation between the gene polymorphism of CYP4F2 and CHD was analyzed.Results：The difference of two allele frequencies between two group was statistically significant（P〈0.01）.After adjusting the age,gender and body mass index,the logistic regression analysis showed that the CHD risk of patients with rs2108622 T allele decreased（P〈0.05）,and the CHD risk of patients with rs3093135 A allele decreased（P〈0.05）.Conclusions：The gene polymorphism of CYP4F2 is correlated with the risk of the CHD in Yunnan Han population.