血清PCT、sTREM-1对肺癌术后并发肺部细菌感染诊断及疗效评估的价值

Application of Serum PCT and sTREM-1 in the Diagnosis of Pulmonary Bacterial Infection after Lung Cancer Surgery

目的探讨血清PCT、s TREM-1对肺癌术后并发肺部细菌感染诊断及疗效评估的价值。方法选择行手术治疗的肺癌患者216例的临床资料进行回顾性分析,其中23例发生术后肺部感染。比较感染患者与未感染患者、治疗好转组与未好转组、好转组治疗前后血清PCT、s TREM-1水平以及CRP水平、乳酸水平等。结果感染组在术后24 h以及48 h后CRP、乳酸、PCT以及s TREM-1均显著高于未感染组,差异有统计学意义(P<0.05)。治疗未好转亚组在术后24 h、术后48 h、感染时、感染后24 h以及感染后48 h CRP、乳酸、PCT以及s TREM-1均显著高于治疗好转亚组,差异有统计学意义(P<0.05)。治疗后,治疗好转组CRP、乳酸、PCT以及s TREM-1显著低于治疗前,差异有统计学意义(P<0.05)。结论动态监测患者PCT、s TREM-1能够及时评估肺癌患者术后发生肺部细菌感染的风险,及时诊断肺部细菌感染,并评估治疗效果。

Objective To discuss the efficacy of serum PCT and sTREM-1 in the diagnosis of pulmonary bacterial infec- tion after lung cancer surgery. Methods Clinical data of 216 cases with lung cancer treated with surgery were retrospectively an- alyzed ,23 cases with postoperative pulmonary infection. PCT, sTREM-1, CRP,lactic acid levels between infected group and unin- fected group,improvement group and deterioration group, before and after treatment of improvement group. Results CRP, lactic acid, PCT and sTREM-11evels at 24 h and 48 h after operation of infection group were higher than those of deterioration group, which showed significant difference （P 〈 0.05 ）. CRP, lactic acid, PCT and sTREM-1 levels at 24 h and 48 h after operation and at infection ,24 h and 48 h after infection of deterioration group were higher than those of improvement group,which showed signifi- cant difference （ P 〈 0.05 ）. After treatment, CRP, lactic acid, PCT and sTREM-1 levels of improvement group after treatment were lower than those before treatment,which showed significant difference （ P 〈 0.05 ）. Conclusion Dynamic monitoring of patients with PEC, sTREM-1 to assess the risk of pulmonary infection in patients with lung cancer, timely diagnosis and evaluate the treat- ment effect.