慢性阻塞性肺疾病急性加重期合并肺部感染239例痰培养和药敏结果分析

Analysis of phlegm raise and medicine sensitive test result in 239 patients with acute exacerbation of COPD incorporate pneumonia

目的:了解慢性阻塞性肺疾病急性加重期肺部感染患者细菌感染趋势及其耐药情况。方法:采用回顾性调查方法,收集239例慢性阻塞性肺疾病急性加重期合并肺部感染老年患者的痰标本进行细菌培养及药物敏感试验。结果:239例住院的慢性阻塞性肺疾病急性加重期合并肺部感染老年患者的痰标本细菌分布以革兰氏阴性菌为主,革兰阳性菌和真菌感染有上升趋势。药物敏感试验显示,大多数革兰阴性菌对广谱抗菌药物耐药,对碳青霉烯类、内酰胺/酶抑制剂类敏感率高。结论:临床上应重视细菌下呼吸道感染的耐药问题,合理使用抗菌药物。

Objective To understand the bacterium infection tendency and drug resistant situation in patients with acute exacerbation of COPD(AECOPD) incorporate pneumonia.Methods 239 patients'phlegm specimen with AECOPD incorporate pneumonia were used to carry on the germ culture and medicine sensitive test.Results The main bacterium of phlegm specimen's bacterium distribution in 239 patients with AECOPD incorporate pneumonia was gram-negative bacterium;gram-positive bacterium infection and mycotic infection were being on the rise in the meanwhile.Medicine sensitive test showed that most of gram-negative bacterium produced drug resistant on broad-spectrum antibiotic and had high sensitivity rate on Carbapenems and β-lactamase /β-lactamase inhibitor.Conclusion Clinicists should pay attention to the drug resistant problem of bacterial infection in low respiratory tract and make rational use of antibiotics.