黄瓜香水提物对大鼠亚急性肝损伤的保护作用

Protective effect of Viola diffusa ging on rats with subacute hepatic injury

目的:研究黄瓜香水提物对大鼠亚急性肝损伤的保护作用。方法:将48只SD大鼠随机分为6组,即空白组,模型组,对照组及药物治疗组(高、中、低剂量治疗组)。采用四氯化碳加乙醇复制亚急性肝损伤模型,以血清丙氨酸氨基转移酶(ALT)、天冬氨酸转氨酶(AST)、碱性磷酸酶(ALP)及肝匀浆中的丙二醛(MDA)及超氧化物歧化酶(SOD)含量为指标,观察黄瓜香水提物对大鼠亚急性肝损伤的保护作用。结果:与模型组比较,黄瓜香水提物高、中、低剂量治疗组ALT、AST、ALP及MDA含量均明显降低(P<0.05),SOD活性明显升高(P<0.05);但与对照组相比无显著差异(P>0.05)。结论:黄瓜香水提物对大鼠亚急性肝损伤具有保护作用。

Objective To research the protective effects of water extract of Viola Diffusa Ging on Subacute hepatic injury.Methods 48 SD rats were randomly divided into six groups,which were the blank control group,the model control group,the positive control group and the drug control groups(The high,the middle and low dose treating group,respectively).Subacute hepatic injury induced by CCl4 and ethanol was selected in rats.ALT,AST and ALP contents in serum and Superoxide dismutase(SOD) and malondialdehyde(MDA) contents in hepatic homogenate were determined.Results Compared with the model group,the contents of ALT,AST,ALP and MDA remarkably decreased(P<0.05),the activity of SOD remarkably improved(P<0.05),but no significant difference was found between the drug control groups and the positive control group(P>0.05).Conclusion Water extract of Viola Diffusa Ging has protective effects on Subacute hepatic injury of rats induced by CCl4 and ethanol.