IL12B基因多态性与卵巢癌的相关性研究

Association of IL12B Polymorphisms with susceptibility to Ovarian Carcinoma

目的:探讨IL12B基因多态性与女性卵巢癌的关系。方法:采用PCR-RFLP技术检测92例卵巢癌患者与38例正常对照者IL12B rs3212227基因多态性。结果:IL12B基因型频率分布在病例组和对照组人群中的差异无统计学意义(p=0.086)。非变异基因型IL12B rs3212227AA与变异基因型IL12B rs3212227AC/CC在两组人群中的分布差异具有显著性(p=0.036),而与AA基因型相比,AC/CC基因型能显著提高卵巢癌的患病风险(OR=2.47;95%可信区间为1.05-5.84)。结论:本研究结果提示,IL12B rs3212227基因多态性与卵巢癌的患病风险有关,其变异提高卵巢癌的发病率,是卵巢癌的危险因子之一。

Objective The aim of this study was to investigate whether IL12B polymorphisms might be associated with increased risk of ovarian carcinoma.Methods We genotyped IL12B rs3212227 by PCR-RFLP in a hospital-based study of 92 ovarian carcinoma cases and 38 cancer-free controls.Results No significant difference was found in frequency distribution of genotypes of IL12B rs 3212227 polymorphisms between cases and controls(P=0.086),while a significant difference was found in frequency distribution of the AA genotype and non-AA genotype between cases and controls(P<0.05),the IL12B rs3212227 AC/CC variant genotypes were associated with a significantly increased risk of ovarian carcinoma [odds ratio,2.47;95% confidence interval(CI),1.05-5.84],compared with their corresponding wild-type homozygotes.Conclusion These findings suggest that IL12B rs3212227 polymorphisms may contribute to the risk of ovarian carcinoma,and variant genotypes may increase the incidence of ovarian carcinoma,as a risk factor for ovarian carcinoma.