辛伐他汀联合抗凝药物治疗老年激素性股骨头坏死临床效果及安全性分析

Clinical Efficacy and Safety of Simvastatin Combined with Anticoagulant in Treatment of Senile Sterioid-Induced Avascular Necrosis of the Femoral Head

目的探讨辛伐他汀联合抗凝药物治疗老年激素性股骨头坏死(SANFH)的临床效果及安全性。方法对2013年2月—2016年2月收治的80例老年SANFH的临床资料做回顾性分析,根据治疗方式分为观察组和对照组,每组40例。观察2组临床疗效、疼痛程度、行走能力、关节功能评分、股骨头塌陷时间、坏死指数及治疗前后血浆黏度和血细胞比容。结果观察组治疗优良率高于对照组(P<0.05)。治疗后2组疼痛程度、行走能力、关节功能评分均较治疗前好转,且观察组疼痛程度轻于对照组,行走能力、关节功能评分均高于对照组(P<0.05)。2组治疗后血浆黏度及血细胞比容均较治疗前下降,且观察组各指标较对照组下降明显(P<0.05)。治疗后2组股骨头坏死指数均较治疗前下降,且观察组股骨头塌陷时间、股骨头坏死指数均低于对照组(P<0.05)。2组不良反应总发生率比较差异无统计学意义(P>0.05)。结论辛伐他汀联合抗凝药物治疗老年SANFH临床效果较好,且安全性较高。

Objective To analyze clinical efficacy and safety of Simvastatin combined with anticoagulant drugs in treatment of senile sterioid-induced avascular necrosis of femoral head （SANFH）. Methods Clinical data of 80 eld- erly patients with SANFH admitted during February 2013 and February 2016 was retrospectively analyzed. Patients were divided into observation group and control group （n = 40 for each group） according to different treatment methods. Clinical efficacy, pain degree, walking ability, joint function score, femoral head collapse time, necrosis index and plasma viscosity and hematoerit levels before and after treatment were observed in two groups. Results The excellent and good rate in observation group was significantly higher than that in control group （ P 〈 0.05 ）. After treatment in two groups, pain degree, walking ability and joint function scores were significantly improved compared with those before treatment （ P 〈 0.05 ） , and values of pain degree, walking ability and joint function scores in observation group were significantly lower than those in control group （ P 〈 0.05 ）. After treatment, plasma viscosity and hematocrit levels were significantly lower than those before treatment in two groups （P 〈 0.05 ） , and the decreased indexes in observation group were signifi- cantly obvious compared with those in control group, （P 〈 0.05 ）. After treatment, femoral head necrosis index levels were significantly decreased in two groups （P 〈 0.05 ） , and values of femoral head collapse time and femoral head necrosis index in observation group were significantly lower than those in control group （ P 〈 0.05 ）. There was no significant difference in total incidence rate of adverse reactions between the two groups （ P 〉 0.05 ）. Conclusion Simvastatin combined with anticoagulant drugs in treatment of senile steroid-induced avascular necrosis of femoral head can achieve good clinical effect with good safe.