运动诱导的肌肉因子与久坐慢性病群

Exercise-induced myokines and sedentary chronic diseases

运动有助于预防和治疗心血管疾病、癌症、糖尿病等久坐慢性病群疾病。这可能是由于骨骼肌具有内分泌和旁分泌功能,收缩肌肉能够释放白细胞介素-6(IL-6)、IL-15、脑源性神经营养因子(BDNF)等具有激素样作用的肌肉因子,交互调节身体各器官、肌肉和脂肪。一些肌肉因子具有内分泌作用,调节内脏脂肪氧化或介导抗炎反应;另一些肌肉因子则经旁分泌机制在肌肉局部和脂肪氧化有关的信号途径中发挥作用。

Exercise can help prevent and treat all of the sedentary chronic diseases such as cancer, diabetes and cardiovascular disease.This may be due to endocrine and paracrine functions of skeletal muscles.Contracted muscles can release some hormones-like myokines, such as interleukin-6 （IL-6）, IL-15, brain-derived neurotrophic factor （BDNF） and others.These myokines play roles in organ cross talk, including interactive adjustment among body organs, muscle and fat.Some myokines exert endocrine function, regulate the oxidation of visceral fat or mediate direct anti-inflammatory effects.While, other myokines play roles in fat oxidation-related signal pathway within the skeletal muscles through paracrine mechanism.