内部核糖体进入位点与肠道病毒

Relationship of internal ribosomal entry site(IRES) and enterovirus

人肠道病毒属于小RNA病毒科,为无包膜单股正链RNA病毒,两端为非编码区(UTR),中间仅有一个编码大分子多聚蛋白的开放阅读框。5'-UTR包含IRES结构,病毒感染宿主后,在关闭帽子依赖翻译的同时,可促进IRES介导的翻译从而有利于病毒的翻译,研究IRES与肠道病毒的关系对于抗病毒治疗至关重要。

Human enteroviruses belonging to Picornaviridae family are nonenveloped virus, which contain a single positive-stranded genomic RNA. The viral genome has 5＇-untranslated region （5＇-UTR）, single open reading frame of encoding polyprotein precursor and 3＇-untranslated region （Y-UTR）. 5＇-UTR RNA contains an internal ribosomal entry site （IRES）. When virus infect host, the IRES-mediated initiation of translation enhance the translation of viral RNA, while at the same time host cell translation is shut off. Research on the relationship between IRES and enterovirus is vitally important to antiviral treatment.