灯盏乙素缓释片的制备及其体外释放度的考察

Preparation of Scutellarin Sustained-relealse Tablets and Its Release Study in Vitro

目的制备灯盏乙素亲水凝胶骨架片,并考察其体外释放行为。方法以HPMC为基本骨架材料,采用L_9(3~4)正交实验设计优选处方;体外释放以灯盏乙素为评价指标,采用UV法进行测定。结果灯盏乙素亲水凝胶骨架片的最佳制备工艺为A_2B_1C_3(HPMC的用量为45mg,HPMC选用E4M,填充剂用量为182mg);批间工艺重现性良好。体外释放接近Higuchi释放特征。结论优选出的灯盏乙素亲水凝胶骨架片制备工艺可行,重现性好,有明显的缓释特征。

Objective To prepare stutellarin Hydrophilic Matrices sustained release tablet , and to investigate its release characteristics in vitro. Methods Using hydroxypropyl methylcell ulose （HPMC） as the matrix material. By L9（34） orthogonal design to study the best preparation technology of stutellarin Hydrophilie Matrices sustained release tablet;the assay of the release in vitro was valued by UV spectrophotometry with breviscapin as evaluating indicator. Results The optimum preparation conditions of stutellarin Hydrophilic Matrices sustained-release tablet were A2B1C3 （The amount of HPMC was 45 mg, E4M HPMC was selected, filler dose of 182 mg）; the repeatability of three batches were good. Its release in vitro is similar with Higuchi release characteristics. Conclusion The preparation procedure of stutellarin Hydrophilic Matrices sustained-release tablet is feasible and repeatable. The tablets have obviously sustained property.