躯体形式疼痛障碍患者脑灰质体积变化及其与NRS评分的关系

Changes of brain gray matter volume in patients with somatoform pain disorder and the relationship with NRS score

目的利用基于头颅MRI的体素形态学分析(VBM)技术,观察躯体形式疼痛障碍(SPD)患者脑灰质体积改变,并分析其与疼痛程度的关系。方法选择SPD患者10例纳入病例组、健康志愿者14例纳入对照组。对SPD患者进行疼痛数字评价量表(NRS)评分。两组均行头颅MRI检查,高分辨3D T1WI数据采集,保存图像。将两组头颅MRI检查所获得的所有图像数据进行VBM,测算全脑体积及灰质体积,并获取两组灰质体积差异有统计学意义的脑区。采用Pearson相关分析法分析SPD患者灰质体积与NRS评分的相关性。结果 VBM显示,病例组灰质体积大于对照组(P<0.01),灰质体积增加的区域主要位于左侧丘脑。病例组左侧丘脑灰质体积与NRS评分无显著相关性(r=0.631,P>0.05)。结论 SPD患者头颅MRI VBM显示脑灰质体积增大,主要位于左侧丘脑;脑灰质体积改变与疼痛程度无明显相关性。

Objective Using voxel-based morphometry （VBM） to investigate the changes of brain gray matter （GM） volume in patients with somatoform pain disorder （SPD） and to explore its relationship with the degree of pain.Methods A total of 10 SPD patients and 14 healthy volunteers were enrolled in this study.The SPD patients were evaluated by the numerical rating scale （NRS）.The SPD patients and healthy volunteers were both examined by head magnetic resonance imaging （MRI）,and 3D T1WI high resolution data were acquired.The whole brain volume and gray matter volume were calculated and the meaningful GM regions of SPD patients were obtained by VBM.The correlation between the GM volume and the NRS scores in SPD patients was analyzed by Pearson analysis.Results VBM showed that the gray matter volume in the SPD group was larger than that in the control group （P〈0.01）,and the regions of increased gray matter volume was mainly located in the left thalamus.There was no significant correlation between the left thalamus gray matter volume and the NRS score in the SPD group （r=0.631,P〉0.05）.Conclusions The head MRI VBM shows brain gray matter volume increases in SPD patients,and it is mainly located in the left thalamus.There is no significant correlation between the changes of brain gray matter volume and the degree of pain.