摘要
背景术后恶心呕吐（post叩erativenauseaandvomiting，PONV）发生率为20％～80％，右美托咪定（dexmedetomidine，Dex）是一种新型的高选择性仅z肾上腺素受体激动剂，近来研究提示，Dex可能在预防和治疗PONV中发挥作用。目的了解Dex预防和治疗PONV的效果。内容综合相关文献，从Dex防治PONV的机制、优势、最佳剂量、应用时间、给药途径等方面探讨其防治PONV的效果。趋向Dex有望成为减少PONV发生的一种新的药物选择。
Background The incidence of postoperative nausea and vomiting （PONV） ranges from 20% to 80%. Dexmedetomidine （Dex） is a potent and highly selective a2 adrenergic receptor agonist and recent studies suggest that Dex may be of vital role in prevention and treatment of PONV. Objective The effect of Dex in PONV prevention and therapy will be reviewed. Content Possible mechanisms, advantages and the best dose, application time and method of Dex in experimental studied were summarized in this review to explore the effect of Dex on the prevention and treatment of PONV. Trend Dex is expected to be a new drug option for reducing PONV.
出处
《国际麻醉学与复苏杂志》
CAS
2017年第7期625-628,共4页
International Journal of Anesthesiology and Resuscitation
关键词
右美托咪定
预防
术后恶心呕吐
Dexmedetomidine
Prevention
Postoperative nausea and vomiting
