趋化因子在骨癌痛机制中的研究进展

Process of chemokines participate in the development of cancer induced bone pain

背景骨癌痛（cancerinducedbonepain，CIBP）是中晚期癌症常见的并发症之一，严重影响癌症患者的生活质量，目前尚缺乏有效的治疗手段。趋化因子是有趋化作用的蛋白质，通过趋化白细胞定向移动的方式来参与免疫应答。近几年研究证明，趋化因子在CIBP的发生及维持中起到很重要的作用。目的了解趋化因子在CIBP发生发展过程中所扮演的角色，从而为CIBP患者提供新的治疗策略。内容综述近几年相关文献，阐述趋化因子及其受体参与CIBP发生与维持的研究进展。趋向趋化因子有望成为CIBP治疗的新靶点。

Background Cancer induced bone pain （CIBP） is very common in patients with late stage cancer, which seriously damage the quality of life among cancer patients, but there is no effective therapy up to now. Chemokine is a kind of protein function in chemotaxis, which direetionally guides white blood cells to migrate to participate in the immune response. In recent years, studies have shown that ehemokines play a very important role in the occurrence and maintain of CIBP. Objective To understand the role of chemokines in the development of CIBP, which will provide a new therapy method for patients with CIBP. Content This article reviews the advances in the study of the ehemokines and CIBP. Trend Chemokines will be new targets for CIBP treatment. [ Key words ] Cancer induced bone pain; Chemokines; Mechanism