SERPINE家族在纤维化疾病中作用的研究进展

Research Progress of SERPINE Family in Fibrosis Disease

丝氨酸蛋白酶抑制剂(Serine Protease Inhibitor,Serpin)是一类丝氨酸蛋白酶活性调节剂,在人体中被分为A^I9个亚家族,其中SERPINE(Serpin Peptidase Inhibitor,Clade E)家族参与调节生物体内多个重要的生命过程。本文通过介绍SERPINE家族中两个重要成员SERPINE1与SERPINE2的理化性质、作用机制以及调控因素,阐述SERPINE家族在纤维化相关疾病中的作用及研究进展。

Serine protease inhibitor （serpin） is a kind of serine protease activity regulator,which including nine subfamilies （SERPIN A - 1）. SERPINE （Serpin Peptidase Inhibitor, Clade E） can regulate many important life processes. In this paper, the physical and chemical properties, mechanisms and regulatory factors of SERPINE1 and SERPINE2 in the two important members of SERPINE family are introduced, and the research progress of SERPINE family in the fibrosis related diseases is described.