可逆性后部脑病综合征发病机制进展及影像学表现

Progress in Pathogenesis of Posterior Reversible Encephalopathy Syndrome and Its Imaging Manifestations

可逆性后部脑病综合征是一种与多种致病因素相关的临床影像学综合征,以头痛、癫痫发作、精神症状、视觉障碍、意识障碍为主要临床表现,影像学以顶枕叶可逆性脑白质病变为主。该病如果能够得到及时的诊断与治疗,大部分患者的临床症状及影像学改变可以消失;如果不能得到及时正确的诊疗,可能会发生一些不可逆的损伤,严重时甚至危及生命,因此加强对本病的认识、诊断及治疗至关重要。目前该病的发病机制尚不明确,现对其发病机制进展及影像学表现进行综述,以提高临床医师对该病的病理生理机制的认识及提高诊断水平。

Posterior reversible encephalopathy syndrome is a clinical imaging syndrome associated with multiple pathogenic factors. The main clinical manifestations were headache, seizures, psychotic symptoms, visual disturbance, disturbance of consciousness, etc. The parieto-occipital reversible white matter lesions are the main manifestations of the imaging. If this disease can be diagnosed and treated in time, the clinical symptoms and imaging changes of most patients can be disappeared. If the diagnosis and treatment cannot be obtained in time, it may happen some irreversible damage, serious and even life-threatening, so it is very important to strengthen the understanding, diagnosis and treatment of this disease. At present, the pathogenesis of the disease is still not clear, now reviewed its pathogenesis and imaging manifestation in order to strengthen the clinician＇s understanding of the disease＇s pathophysiological mechanism and improve the level of diagnosis.