弥散加权成像及~1H磁共振波谱在新生儿缺氧缺血性脑病中的诊断价值

Diagnostic Value of Diffusion Weighted Imaging and ~1H Magnetic Resonance Spectroscopy for the Neonates with Hypoxic Ischemic Encephalopathy

目的:探讨弥散加权成像、1H磁共振波谱诊断新生儿缺氧缺血性脑病的应用价值。方法:以本院收治的缺氧缺血性脑病新生儿37例为研究组,另选择健康新生儿40例作为对照组,两组新生儿均接受弥散加权成像及1H磁共振波谱检查,观察研究组新生儿普通MRI与弥散加权成像检查结果,对比研究组和对照组新生儿的脑代谢化合物相对浓度。结果:与普通MRI检出率相比,研究组患儿的弥散加权成像信号明显升高,差异存在统计学意义(P<0.05)。研究组NAA/Cr比值低于对照组,Cho/Cr、MI/Cr、Glu-Gln/Cr、Lac/Cr比值高于对照组,差异存在统计学意义(P<0.05)。结论:临床上诊断新生儿缺氧缺血性脑病时,弥散加权成像与1H磁共振波谱的联合应用可提升诊断准确率,通过对代谢物浓度的分析有利于评价缺氧缺血导致脑组织损害的严重程度。

Objective： To investigate the diagnostic value of diffusion weighted imaging and 1H magnetic resonance spectroscopy for the neonatal hypoxic ischemic encephalopathy （HIE）. Methods： 37 cases of patients with neonatal hypoxic ischemic encephalopathy admitted in our hospital were selected as the study group, another 40 healthy neonates were selected as the control group, both groups of neonates underwent diffusion-weighted imaging and 1H magnetic resonance spectroscopy, ordinary MRI and diffusion weighted imaging findings of neonates in the study group were observed, the neonatal cerebral metabolic compounds relative concentration were observed and compared between two groups. Results： The detection rate of diffusion-weighted imaging was significantly higher compared with the ordinary MRI （P〈0.05）. The relative ratio of brain metabolic compounds NAA/Cr of study group were obviously lower than those of the control group, while the Cho/Cr, MI/Cr, Glu-Gln/Cr, Lac/Cr were significantly higher （P〈0.05）. Conclusion： Diffusion weighted imaging combined with 1H magnetic resonance spectroscopy could improve the diagnostic accuracy of neonatal hypoxic ischemic encephalopathy, the analysis of the concentrations of brain metabolic compounds could contribute to evaluate the severity of HIE.