新疆克拉玛依市独山子区3527例健康体检人群妇女人乳头瘤状病毒基因亚型的检测及分析

Test and analysis about genetic subtypes of human papilloma virus in Women in Xinjiang Karamay

目的了解本地区健康体检妇女宫颈人乳头瘤状(humanpapillomavirus,HPV)感染状况和亚型分布,为宫颈癌的防治提供理论依据。方法对体检女性采用多重聚合酶链反应(PCR)荧光检测法检测并分析其感染率及年龄分布。结果 3527例女性中共检出HPV阳性673例,占总检测人数19.08%。阳性患者中以16型及52型为主,年龄在30~49岁居多。16型118例最多,占总阳性的17.53%;45型最少,10例占阳性的1.49%。结论健康体检女性中有相当的比例感染HPV,尤其是高危型。对体检女性进行HPV DNA检测及分型有重要意义。

Objective To investigate the status and subtypes among women who having physical examination and enduring with cervical human papillomavirus（humanpapillomavirus,HPV） infection in this region, and to provide a theoretical basis for the prevention of cervical cancer. Methods Prevalence and age distribution among women having physical examination were detected and analyzed by multiplex polymerase chain reaction（PCR） and, fluorescence detection method. Results Among 3527 female cases, 673 cases were HPV positive, accounting for 19.08%. The type of HPV were mainly type 16 and type 52, and ages of positive cases ranged from 30 to 49 years old. Type 16 were about 118 cases which was the most, accounting for 17.53%; Type 45 accounted for 1.49% which was the least.Conclusion The proportion of examined cases who were infected with HPV was high, and the type was high-risk type. It is significantly important to detect HPV through DNA test and classify what the type was.