益心舒胶囊对急性心肌梗死后焦虑抑郁情绪及生活质量影响

Effects of Yixinshu Capsule on Anxiety-Depression Symptom and Quality of Life in Patients with Acute Myocardial Infarction

目的:调查急性心肌梗死(AMI)后,患者焦虑、抑郁情绪和生活质量,及应用益心舒胶囊对其影响。方法:选取2014年1月至2015年12月在南阳市中心医院住院治疗的AMI患者共517例。根据焦虑自评量表(SAS)及抑郁自评量表(SDS),共发现AMI合并焦虑患者102例,合并抑郁患者89例,同时合并焦虑及抑郁患者63例。将合并焦虑及抑郁患者随机分为观察组与对照组。对照组应用常规治疗药物,观察组在其基础上应用益心舒胶囊。观察其对患者生活质量和焦虑、抑郁情绪的影响及不良反应发生情况。结果:2组患者基线情况差异无统计学意义(P>0.05),治疗前2组患者生活质量及汉密尔顿焦虑量表(HAMA)评分、抑郁量表(HRSD)评分差异均无统计学意义(P>0.05)。治疗1个月后,观察组生活质量评分与对照组比较,差异有统计学意义(P<0.05或P<0.01),HAMA、HRSD评分均显著低于对照组(P<0.05)。治疗3个月后,观察组生活质量及HAMA、HRSD评分与对照组比较差异均有统计学意义(P<0.01)。结论:益心舒胶囊可降低焦虑、抑郁评分,具有改善AMI患者焦虑和抑郁情绪作用。

Objective： To investigate the patients′ state of anxiety-depression symptom and quality of life after acute myocardial infarction and the influence of Yixinshu Capsule on patients.Methods： Five hundred and seventeen patients with acute myocardial infarction were included from Nanyang Central Hospital from January 2014 to December 2015. Based on Self-Rating Depression Scale （SDS） and Self-Rating Anxiety Scale （SAS）, 102 patients with anxiety, 89 patients with depression, and 63 patients with anxiety and depression were selected.Patients with both anxiety and depression were randomly divided into the experimental and control group.Patients in the control group received conventional treatment, while patients in the experimental group additionally received Yixinshu Capsule.The therapeutic effects and adverse reactions and the impact on patients′ quality of life and incidence of anxiety and depression were observed.Results： The baseline data no significant difference between two groups （P〉0.05）, Quality of life and HAMA score, HRSP score before treatment no significant difference （P〉0.05）.After one-month′s treatment, the quality of life of the treatment group showed significant difference compared with that of the control group （P〈0.05, P〈0.01）;HAMA scores and HRSP score of the treatment group was significantly lower than those of the control group （P〈0.05）.After 3 months′ treatment, scores for quality of life, HAMA scores and HRSP scores showed remarkably significant difference between the two groups （P〈0.01）.Conclusion： Yixinshu Capsule may relieve anxiety and depression and improve quality of life in patients with acute myocardial infarction.