Scc、CA125和Ki67在宫颈癌和癌前病变诊断中的价值

Significance of Scc, CA125 and Ki67 in diagnosis of cervical cancer and precancerous lesions

目的探讨鳞状上皮细胞癌抗原Scc、CA125和Ki67在宫颈癌和癌前病变诊断中的价值。方法收集18例正常宫颈、46例宫颈上皮瘤样病变和52例宫颈癌患者,采用化学发光法检测患者血清中Scc、CA125水平,免疫组化SP法检测患者标本中Ki67的表达,并比较3项指标单项检测与联合检测的灵敏度及特异性。结果癌变组患者血清中Scc、CA125水平及Ki67阳性表达率均显著高于瘤变组和正常组(P<0.05);3项指标联合检测的灵敏度及特异性明显高于任一单项指标的灵敏度和特异性。结论 Scc、CA125、Ki67联合检测可作为早期诊断宫颈癌前病变及宫颈癌的标记物,可提高宫颈癌的早期诊断率。

Objective To investigate the significance of squamous cell carcinoma antigens Scc, CA125 and Ki67 in diagnosis of cervical cancer and precancerous lesions. Methods Serum samples were collected from 18 healthy women,46 patients with cervical epithelium benign lesions and 52 patients with cervical cancer, and determined for Scc and CA125 levels by chemiluminescence immunoassay, and for expression of Ki67 by immunohistochemical SP method. The sensitivities and specificities of test for a single index and combined test for three indexes were compared. Results The Scc and CA125 levels and Ki67 expression rate in the patients with cervical cancer were significantly higher than those with cervical epithelium benign lesions and those of healthy women（P 〈 0. 05）. The sensitivity and specificity of combined test for three indexes were significantly higher than those for any single index. Conclusion Scc, CA125 and Ki67 may be used as the markers of early diagnosis of cervical lesions and cervical cancer, of which the combined determination may increase the early diagnosis rate of cervical cancer.