“通经调脏”治疗代谢综合征胃肠实热证的临床研究

Clinical Research of Tongjing Tiaozang( 通经调脏) Treatment on Metabolic Syndrome Patients with Stomach-Intestine Excessive Heat

目的:观察"通经调脏"法治疗代谢综合征胃肠实热证的临床疗效。方法:60例胃肠实热证代谢综合征患者,随机分为对照组(30例)和观察组(30例)。观察组给予中药代谢实证方联合低频脉冲电治疗,对照组给予盐酸二甲双胍口服治疗,治疗3个月后,观察2组患者治疗前后中医证候疗效,检测治疗前后2组患者血糖、血脂等理化指标。结果:2组患者治疗后中医证候疗效比较:观察组总有效率为86.7%,对照组为63.3%,2组间比较差异有统计学意义(P<0.05)。与治疗前比较,2组FPG、2 h PG、Hb A1C均有明显降低(P<0.05,P<0.01);观察组治疗后TG水平显著降低,差异有统计学意义(P<0.01);对照组TG变化无统计学意义(P>0.05);治疗后2组FPG比较,无统计学差异(P>0.05),2h PG、Hb A1C、TG比较有显著差异(P<0.01)。2组患者治疗后体质量、BMI、腰围较治疗前均有所下降,但无统计学意义(P>0.05)。结论:通经调脏(中药联合低频脉冲电治疗)能够改善代谢综合征(胃肠实热证)临床症状,降低血糖、血脂水平。

Objective： To observe the clinical effect of Tongjing Tiaozang treatment on metabolic syndrome. Methods： Sixty patients of metabolic syndrome, were randomly divided into control group （30 cases） and treatment group （30 cases）. Tongjing Tiaozang treatment：metabolic empirical formula combined with low frequency pulse electric therapy,was given to treatment group. Control group was treated with mefformin. During 3 months of treatment, observed the improving of physical and chemical examinations and clinical symptoms. Results： The total efficacy of Chinese medicine syndrome was 86. 7% in treatment group ,that was better than that of control group which was 63.3% （P 〈0. 05）. Compared with treatment before, fasting plasma glucose （FPG）, 2 hours plasma glucose （2hPG）, glycated hemoglobin （ HbA1c） were statistically significant （ P 〈 0. 05, P 〈 0. 01 ） in each group. In the treatment group, triglyceride （ TG ） had significant difference （ P 〈 0. 01 ）, but not in the control group（ P 〉 0. 05 ）. After treatment, significant difference exist in 2 hPG, HbA~ c and TG between the two groups（P 〈 0.01）, but not in FPG （P 〉 0.05）. The weight, body mass index （BMI） and waist circumfer- ence of the two groups were decreased, but there was no statistical difference （P 〉 0. 05 ）. Conclusion： Tongjing Tiao- zang treatment can improve clinical symptoms, regulated levels of blood glucose and lipid on metabolic syndrome patients with stomach -intestine excessive heat.